Adaptive immunity in obesity and insulin resistance

H Sell, C Habich, J Eckel - Nature Reviews Endocrinology, 2012 - nature.com
Obesity is the hallmark of the metabolic syndrome and predisposes patients to the
development of major chronic metabolic diseases including type 2 diabetes mellitus …

[HTML][HTML] Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function

AR Martins, RT Nachbar, R Gorjao, MA Vinolo… - Lipids in health and …, 2012 - Springer
Insulin resistance condition is associated to the development of several syndromes, such as
obesity, type 2 diabetes mellitus and metabolic syndrome. Although the factors linking …

Molecular targets related to inflammation and insulin resistance and potential interventions

SM Hirabara, R Gorjao, MA Vinolo… - BioMed Research …, 2012 - Wiley Online Library
Inflammation and insulin resistance are common in several chronic diseases, such as
obesity, type 2 diabetes mellitus, metabolic syndrome, cancer, and cardiovascular diseases …

Mitochondria: commanders of innate immunity and disease?

SM Cloonan, AMK Choi - Current opinion in immunology, 2012 - Elsevier
Mitochondrial dysfunction is associated with the manifestation and origin of a plethora of
diseases and disorders. Whilst classically the role of these archetypical 'powerhouses' in …

Secondary muscle pathology and metabolic dysregulation in adults with cerebral palsy

MD Peterson, PM Gordon… - American Journal of …, 2012 - journals.physiology.org
Cerebral palsy (CP) is caused by an insult to or malformation of the developing brain which
affects motor control centers and causes alterations in growth, development, and overall …

SIRT1 in metabolic syndrome: where to target matters

Y Wang, C Xu, Y Liang, PM Vanhoutte - Pharmacology & therapeutics, 2012 - Elsevier
Sirtuin 1 (SIRT1), the mammalian ortholog of yeast Sir2p, is a highly conserved NAD+-
dependent protein deacetylase that has emerged as a key cardiometabolic regulator. During …

[HTML][HTML] Fraction from Wax Apple [Syzygium samarangense (Blume) Merrill and Perry] Fruit Extract Ameliorates Insulin Resistance via Modulating Insulin Signaling …

SC Shen, WC Chang, CL Chang - International journal of molecular …, 2012 - mdpi.com
Inflammation is associated with the development of insulin resistance in Type 2 diabetes
mellitus. In the present study, mouse FL83B cells were treated with tumor necrosis factor …

Retroperitoneal white adipose tissue mitochondrial function and adiponectin expression in response to ovariectomy and 17β-estradiol replacement

E Amengual-Cladera, I Lladó, M Gianotti, AM Proenza - Steroids, 2012 - Elsevier
Sexual dimorphism has been previously found both in mitochondrial biogenesis and
function and in adiponectin expression of retroperitoneal WAT. However, little is known …

[HTML][HTML] Lipid overload: trigger or consequence of mitochondrial oxidative stress in ventilator-induced diaphragmatic dysfunction?

E Lecuona, CS Sassoon, E Barreiro - American journal of …, 2012 - atsjournals.org
The patient population in the cohort was from the younger pediatric age group, and the
authors acknowledge the limitation of feedback from the patient. The data do not cover all …