Aging is a multifactorial process resulting in damage of molecules, cells, and tissues. It has
been demonstrated that the expression and activity of antioxidant systems (SOD, HSPs) are …

Sirtuin 1 (SIRT1), the mammalian ortholog of yeast Sir2p, is a highly conserved NAD+-
dependent protein deacetylase that has emerged as a key cardiometabolic regulator. During …

The protein deacetylase, sirtuin 1, is suggested as a master regulator of exercise-induced
beneficial effects. Sirtuin 1 modulates mitochondrial biogenesis, primarily via its ability to …

As a signaling molecule and an inhibitor of histone deacetylases (HDACs), butyrate exerts
its impact on a broad range of biological processes, such as apoptosis and cell proliferation …

Calorie restriction (CR) extends lifespan and delays onset of age-related diseases in various
organisms, even when started later in life. Despite benefits for health and lifespan, CR's …

오래 살고 싶은 것은 누구나 꿈꾸는 일이다. 의학의 눈부신 발전에 의해많은 생명을 앗아 갔던
질병들이 정복되고, 과거에 비해 평균수명이 증가하였으나, 인간의 평균 수명은 2010 년 한국을 …

Moderate aerobic exercise reduces oxidative stress, intense physical activity may produce
the opposite result. At present, the effects of different exercise loads on oxidative stress …