Comparative assessment of antioxidant and cholinesterase inhibitory properties of the marigold extracts from Calendula arvensis L. and Calendula officinalis L.

T Ercetin, FS Senol, IE Orhan, G Toker - Industrial Crops and Products, 2012 - Elsevier
Calendula sp. is an important medicinal and industrial plant with various bioactivities. In this
study, we examined enzyme inhibitory effects of the n-hexane, dichloromethane, acetone …

Phenolic acids from malt are efficient acetylcholinesterase and butyrylcholinesterase inhibitors

D Szwajgier, K Borowiec - Journal of the Institute of Brewing, 2012 - Wiley Online Library
Anticholinesterase activities of mashes produced using wheat ('Wheat Pale') or barley malts
('Pilsner','Pale Ale','Munich Light','Carahell'or 'Carared') were studied by spectrophotometric …

L-3-n-butylphthalide improves cognitive deficits in rats with chronic cerebral ischemia

J Xu, Y Wang, N Li, L Xu, H Yang, Z Yang - Neuropharmacology, 2012 - Elsevier
3-n-Butylphthalide (NBP) has been shown to have protective effects against ischemic stroke.
In the present study, we investigated effects of l-3-n-butylphthalide (l-NBP) on the learning …

Anticholinesterase potential of flavonols from paper mulberry (Broussonetia papyrifera) and their kinetic studies

HW Ryu, MJ Curtis-Long, S Jung, IY Jeong, DS Kim… - Food chemistry, 2012 - Elsevier
It is necessary to develop food additives to help treat chronic disorders like
neurodegenerative diseases from medicinal plants. Ethanol extracts of paper mulberry were …

Design, synthesis, and bioevaluation of benzamides: novel acetylcholinesterase inhibitors with multi-functions on butylcholinesterase, Aβ aggregation, and β …

DY Peng, Q Sun, XL Zhu, HY Lin, Q Chen… - Bioorganic & medicinal …, 2012 - Elsevier
Alzheimer's disease (AD) is a multifactorial syndrome with several target proteins
contributing to its etiology. In this study, we conducted a structure-based design and …

New cholinesterase inhibiting bisbenzylisoquinoline alkaloids from Abuta grandifolia

MF Cometa, S Fortuna, G Palazzino, MT Volpe… - Fitoterapia, 2012 - Elsevier
The phytochemical study of the stem bark and wood of Abuta grandifolia (Mart.) Sandwith
led to the identification of four bisbenzylisoquinoline alkaloids (BBIQs), namely (R, S)-2 N …

The exploration of thienothiazines as selective butyrylcholinesterase inhibitors

D Karlsson, A Fallarero, G Brunhofer, C Mayer… - European Journal of …, 2012 - Elsevier
The role of butyrylcholinesterase (BChE) in the progression of Alzheimer's disease (AD) has
recently become more crucial. In the AD brain, selective BChE inhibitors have been …

Efficient near-infrared in vivo imaging of amyoid-β deposits in Alzheimer's disease mouse models

A Schmidt, J Pahnke - Journal of Alzheimer's Disease, 2012 - content.iospress.com
The development of early diagnostic and prognostic tools for the visualization of amyloid-β
(Aβ) deposits is one important focus of current imaging research. In patients with Alzheimer's …

[PDF][PDF] Screening for cholinesterase inhibitors in selected fruits and vegetables

D Szwajgier, K Borowiec - Electronic Journal of Polish Agricultural …, 2012 - ejpau.media.pl
Plants deliver a great number of compounds among which some of them can exert a
beneficial therapeutic role in the treatment of Alzheimer's disease (eg huperzine A …

Identification and characterization of diarylimidazoles as hybrid inhibitors of butyrylcholinesterase and amyloid beta fibril formation

D Karlsson, A Fallarero, G Brunhofer, P Guzik… - European journal of …, 2012 - Elsevier
In this contribution, a chemical collection of aromatic compounds was screened for inhibition
on butyrylcholinesterase (BChE)'s hydrolase activity using Ellman's reaction. A set of …