[HTML][HTML] G-protein-coupled receptors in intestinal chemosensation

F Reimann, G Tolhurst, FM Gribble - Cell metabolism, 2012 - cell.com
Food intake is detected by the chemical senses of taste and smell and subsequently by
chemosensory cells in the gastrointestinal tract that link the composition of ingested foods to …

[HTML][HTML] Structure and mechanism for recognition of peptide hormones by Class B G-protein-coupled receptors

K Pal, K Melcher, HE Xu - Acta pharmacologica sinica, 2012 - nature.com
Class B G-protein-coupled receptors (GPCRs) are receptors for peptide hormones that
include glucagon, parathyroid hormone, and calcitonin. These receptors are involved in a …

Headache and prolonged dilatation of the middle meningeal artery by PACAP38 in healthy volunteers

FM Amin, MS Asghar, S Guo, A Hougaard… - …, 2012 - journals.sagepub.com
Aim: To explore a possible relationship between vasodilatation and delayed headache we
examined the effect of pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) on …

[HTML][HTML] Cellular and molecular specificity of pituitary gland physiology

C Perez-Castro, U Renner, MR Haedo… - Physiological …, 2012 - journals.physiology.org
The anterior pituitary gland has the ability to respond to complex signals derived from central
and peripheral systems. Perception of these signals and their integration are mediated by …

Dural mast cell degranulation is a putative mechanism for headache induced by PACAP-38

M Baun, MHF Pedersen, J Olesen… - …, 2012 - journals.sagepub.com
Background: Pituitary adenylate cyclase activating peptide-38 (PACAP-38) has been shown
to induce migraine in migraineurs, whereas the related peptide vasoactive intestinal peptide …

Exogenous administration of PACAP alleviates traumatic brain injury in rats through a mechanism involving the TLR4/MyD88/NF-κB pathway

SS Mao, R Hua, XP Zhao, X Qin, ZQ Sun… - Journal of …, 2012 - liebertpub.com
Pituitary adenylate cyclase-activating polypeptide (PACAP) is effective in reducing axonal
damage associated with traumatic brain injury (TBI), and has immunomodulatory properties …

[HTML][HTML] Comprehensive behavioral analysis of pituitary adenylate cyclase-activating polypeptide (PACAP) knockout mice

S Hattori, K Takao, K Tanda, K Toyama… - Frontiers in behavioral …, 2012 - frontiersin.org
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide acting as a
neurotransmitter, neuromodulator, or neurotrophic factor. PACAP is widely expressed …

G-protein-coupled receptors in adult neurogenesis

VA Doze, DM Perez - Pharmacological reviews, 2012 - ASPET
The importance of adult neurogenesis has only recently been accepted, resulting in a
completely new field of investigation within stem cell biology. The regulation and functional …

[HTML][HTML] Induction of RAGE shedding by activation of G protein-coupled receptors

VV Metz, E Kojro, D Rat, R Postina - 2012 - journals.plos.org
The multiligand R eceptor for A dvanced G lycation E nd products (RAGE) is involved in
various pathophysiological processes, including diabetic inflammatory conditions and …

[HTML][HTML] Suppression of PDGF-induced PI3 kinase activity by imatinib promotes adipogenesis and adiponectin secretion

S Fitter, K Vandyke, S Gronthos… - Journal of molecular …, 2012 - jme.bioscientifica.com
We have isolated a highly expressed splice variant mRNA of murine estrogen receptor-beta
(ERbeta), mERbeta2, containing an in-frame 54 nucleotide insertion between exons 5 and 6 …