BiP‐mediated closing of the Sec61 channel limits Ca2+ leakage from the ER
In mammalian cells, signal peptide‐dependent protein transport into the endoplasmic
reticulum (ER) is mediated by a dynamic protein‐conducting channel, the Sec61 complex …
reticulum (ER) is mediated by a dynamic protein‐conducting channel, the Sec61 complex …
Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells
S Lang, J Benedix, SV Fedeles, S Schorr… - Journal of cell …, 2012 - journals.biologists.com
Co-translational transport of polypeptides into the endoplasmic reticulum (ER) involves the
Sec61 channel and additional components such as the ER lumenal Hsp70 BiP and its …
Sec61 channel and additional components such as the ER lumenal Hsp70 BiP and its …
Efficient secretion of small proteins in mammalian cells relies on Sec62-dependent posttranslational translocation
AKK Lakkaraju, R Thankappan, C Mary… - Molecular biology of …, 2012 - Am Soc Cell Biol
Mammalian cells secrete a large number of small proteins, but their mode of translocation
into the endoplasmic reticulum is not fully understood. Cotranslational translocation was …
into the endoplasmic reticulum is not fully understood. Cotranslational translocation was …
Defective ER associated degradation of a model luminal substrate in yeast carrying a mutation in the 4th ER luminal loop of Sec61p
MC Wheeler, N Gekakis - Biochemical and biophysical research …, 2012 - Elsevier
The major constituent of the eukaryotic ER protein-translocation channel (Sec61p in yeast,
Sec61α in higher eukaryotes) shows a high degree of evolutionary conservation from yeast …
Sec61α in higher eukaryotes) shows a high degree of evolutionary conservation from yeast …
Probing protein import machineries of different organisms with the lipid bilayer technique: functional comparison and phylogenetic insights
A Harsman - 2012 - repositorium.uni-osnabrueck.de
Im Rahmen dieser Arbeit wurde die Konservierung elektrophysiologischer Charakteristika
von Proteintranslokasen aus verschiedenen Organismen untersucht. Die Sec61/Sec61p …
von Proteintranslokasen aus verschiedenen Organismen untersucht. Die Sec61/Sec61p …
[PDF][PDF] Charakterisierung der Funktionen und Regulationsmechanismen des humanen Sec61 Komplexes auf zellulärer Ebene
S Lang - 2012 - publikationen.sulb.uni-saarland.de
This study was aimed to characterize the human endoplasmic reticulum (ER) translocase at
the cellular level in terms of its functions and regulatory mechanisms. The attention has been …
the cellular level in terms of its functions and regulatory mechanisms. The attention has been …
[PDF][PDF] Nachweis und Charakterisierung des post-translationalen Transports kleiner Proteine in das Endoplasmatische Retikulum des Säugers
V Stokes - zhb.uni-luebeck.de
Die eukaryontische Zelle besitzt eine Vielzahl von Organellen, wie beispielsweise den
Zellkern, die Mitochondrien, das Endoplasmatische Retikulum (ER) oder den Golgi-Apparat …
Zellkern, die Mitochondrien, das Endoplasmatische Retikulum (ER) oder den Golgi-Apparat …
On the quaternary structure and gating of the bacterial protein translocation channel
K Dalal - 2012 - open.library.ubc.ca
The SecY protein-conducting channel associates with different cytosolic partners to drive the
translocation of preprotein substrates across the bacterial inner membrane. In this thesis …
translocation of preprotein substrates across the bacterial inner membrane. In this thesis …