Multiple roles for orexin/hypocretin in addiction
Orexins/hypocretins are hypothalamic peptides involved in arousal and wakefulness, but
also play a critical role in drug addiction and reward-related behaviors. Here, we review the …
also play a critical role in drug addiction and reward-related behaviors. Here, we review the …
CNS regulation of appetite
This article reviews the regulation of appetite from a biopsychological perspective. It
considers psychological experiences and peripheral nutritional systems (both episodic and …
considers psychological experiences and peripheral nutritional systems (both episodic and …
Daytime sleepiness in obesity: mechanisms beyond obstructive sleep apnea—a review
LA Panossian, SC Veasey - Sleep, 2012 - academic.oup.com
Increasing numbers of overweight children and adults are presenting to sleep medicine
clinics for evaluation and treatment of sleepiness. Sleepiness negatively affects quality of …
clinics for evaluation and treatment of sleepiness. Sleepiness negatively affects quality of …
Hypocretins and the neurobiology of sleep–wake mechanisms
L de Lecea - Progress in brain research, 2012 - Elsevier
In 1998, our group discovered a cDNA that encoded the precursor of two putative
neuropeptides that we called hypocretins for their hypothalamic expression and their …
neuropeptides that we called hypocretins for their hypothalamic expression and their …
Brain orexin promotes obesity resistance
Resistance to obesity is becoming an exception rather than the norm, and understanding
mechanisms that lead some to remain lean in spite of an obesigenic environment is critical if …
mechanisms that lead some to remain lean in spite of an obesigenic environment is critical if …
Convergent inputs from electrically and topographically distinct orexin cells to locus coeruleus and ventral tegmental area
JA González, LT Jensen, L Fugger… - European Journal of …, 2012 - Wiley Online Library
Abstract Orexin/hypocretin (orx/hcrt) neurons are thought to ensure that reward‐seeking is
accompanied by alertness, but the underlying circuit organization is unclear. Reports of …
accompanied by alertness, but the underlying circuit organization is unclear. Reports of …
Topiramate treatment improves hypothalamic insulin and leptin signaling and action and reduces obesity in mice
AM Caricilli, E Penteado, LL de Abreu… - …, 2012 - academic.oup.com
Topiramate (TPM) treatment has been shown to reduce adiposity in humans and rodents.
The reduction in adiposity is related to decreased food intake and increased energy …
The reduction in adiposity is related to decreased food intake and increased energy …
Orexin and central regulation of cardiorespiratory system
IZ Shahid, AA Rahman, PM Pilowsky - Vitamins & Hormones, 2012 - Elsevier
The hypothalamic peptide orexin plays a role in many physiological systems including
feeding behavior, sleep–wakefulness, reward system, stress, and nociception. In addition, it …
feeding behavior, sleep–wakefulness, reward system, stress, and nociception. In addition, it …
Orexins: tissue localization, functions, and its relation to insulin secretion and diabetes mellitus
E Adeghate - Vitamins & Hormones, 2012 - Elsevier
Orexins play a role in many biological functions include sleep, feeding, and energy balance.
They also regulate circadian rhythms and the way that we feel pain. Orexins have been …
They also regulate circadian rhythms and the way that we feel pain. Orexins have been …
Effects of orexin and glucose microinjected into the hypothalamic paraventricular nucleus on gastric acid secretion in conscious rats
N Chaleek, M Kermani, A Eliassi… - …, 2012 - Wiley Online Library
Background Orexin‐A is a novel peptide that appears to play a role in regulation of gastric
acid secretion. However, little is known about sites of its action. In addition, evidences …
acid secretion. However, little is known about sites of its action. In addition, evidences …