[HTML][HTML] RNA-based therapeutics: current progress and future prospects
JC Burnett, JJ Rossi - Chemistry & biology, 2012 - cell.com
Recent advances of biological drugs have broadened the scope of therapeutic targets for a
variety of human diseases. This holds true for dozens of RNA-based therapeutics currently …
variety of human diseases. This holds true for dozens of RNA-based therapeutics currently …
Nanoparticle-based delivery of small interfering RNA: challenges for cancer therapy
During recent decades there have been remarkable advances and profound changes in
cancer therapy. Many therapeutic strategies learned at the bench, including monoclonal …
cancer therapy. Many therapeutic strategies learned at the bench, including monoclonal …
Pulmonary delivery of therapeutic siRNA
Small interfering RNA (siRNA) has a huge potential for the treatment or prevention of various
lung diseases. Once the RNA molecules have successfully entered the target cells, they …
lung diseases. Once the RNA molecules have successfully entered the target cells, they …
Progress toward in vivo use of siRNAs-II
GR Rettig, MA Behlke - Molecular therapy, 2012 - cell.com
RNA interference (RNAi) has been extensively employed for in vivo research since its use
was first demonstrated in mammalian cells 10 years ago. Design rules have improved, and it …
was first demonstrated in mammalian cells 10 years ago. Design rules have improved, and it …
MicroRNAs in inflammation and immune responses
J Contreras, DS Rao - Leukemia, 2012 - nature.com
MicroRNAs (miRNAs) are important regulators of gene expression in the immune system. In
a few short years, their mechanism of action has been described in various cell lineages …
a few short years, their mechanism of action has been described in various cell lineages …
Endosomal escape pathways for non-viral nucleic acid delivery systems
Nucleic acids, including plasmid DNA (pDNA) and small interfering RNA (siRNA), are
potential therapeutic macromolecules that have been widely explored for the treatment or …
potential therapeutic macromolecules that have been widely explored for the treatment or …
Polycation-based nanoparticle delivery of RNAi therapeutics: adverse effects and solutions
B Ballarin-Gonzalez, KA Howard - Advanced drug delivery reviews, 2012 - Elsevier
Small interfering RNA (siRNA) that silence genes by the process of RNA interference offers
a new therapeutic modality for disease treatment. Polycation-based nanoparticles termed …
a new therapeutic modality for disease treatment. Polycation-based nanoparticles termed …
Supramolecular assemblies in functional siRNA delivery: where do we stand?
The discovery of RNA interference (RNAi) has excited the scientific field due to its potential
for wide range of therapeutic applications. The pharmacological mediator of RNAi, short …
for wide range of therapeutic applications. The pharmacological mediator of RNAi, short …
Respiratory syncytial virus NS1 protein colocalizes with mitochondrial antiviral signaling protein MAVS following infection
S Boyapalle, T Wong, J Garay, M Teng… - PloS one, 2012 - journals.plos.org
Respiratory syncytial virus (RSV) nonstructural protein 1 (NS1) attenuates type-I interferon
(IFN) production during RSV infection; however the precise role of RSV NS1 protein in …
(IFN) production during RSV infection; however the precise role of RSV NS1 protein in …
[HTML][HTML] Management of respiratory viral infections in hematopoietic cell transplant recipients
DP Shah, SS Ghantoji, VE Mulanovich… - American journal of …, 2012 - ncbi.nlm.nih.gov
Advances in stem cell transplantation procedures and the overall improvement in the clinical
management of hematopoietic cell transplant (HCT) recipients over the past 2 decades have …
management of hematopoietic cell transplant (HCT) recipients over the past 2 decades have …