Unlike their protein “roommates” and their nucleic acid “cousins," carbohydrates remain an
enigmatic arm of biology. The central reason for the difficulty in fully understanding how …

The major histocompatibility complex (MHC) glycoprotein family, also referred to as human
leukocyte antigens, present endogenous and exogenous antigens to T lymphocytes for …

Invariant natural killer T (i NKT) cells are restricted by the non-polymorphic MHC class I-like
protein, CD1d, and activated following presentation of lipid antigens bound to CD1d …

Invariant natural killer T (i NKT) cells are a specialised subset of T cells that are restricted to
the MHC class I like molecule, CD 1d. The ligands for i NKT cells are lipids, with the …

Human invariant natural killer T (NKT) cell TCRs bind to CD1d via an “invariant” Vα24‐Jα18
chain (iNKTα) paired to semi‐invariant Vβ11 chains (iNKTβ). Single‐amino acid variations at …

US8227581B2 - Modified α-galactosyl ceramides for staining and stimulating natural killer T
cells - Google Patents US8227581B2 - Modified α-galactosyl ceramides for staining and …

Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative procedure for a
number of hematological malignancies including leukemia and lymphoma. However, the …

Compositions comprising the compound of formula are provided herein. Also provided are
methods of enhancing an immune response of a subject to an antigen by administering the …

Although natural killer T cells comprise only a small proportion of lymphocytes, they have
profound effects on immune function. NKT cells are equipped to rapidly respond to …

Natural killer T (NKT) cells represent an heterogeneous T cell population involved in host
immunity against several microorganisms. They also have important immunoregulatory …