CCR7 is a homeostatically expressed chemokine receptor that is known to regulate the
homing of various types of immune cells to primary, secondary, and tertiary lymphoid …

Background Histone deacetylase inhibitors (HDACi) display potent therapeutic efficacy in
animal models of arthritis and suppress inflammatory cytokine production in rheumatoid …

Resident cells, such as fibroblast-like synoviocytes (FLS), play a crucial role in rheumatoid
arthritis (RA). They are implicated in the inflammatory response and play a key role in …

Objectives. Biologic drugs have revolutionized the care of RA, but are expensive and not
universally effective. To further understand the inflammatory mechanisms underlying RA and …

Adipokines such as adiponectin and visfatin/pre-B-cell colony-enhancing factor (PBEF) have
been recently shown to contribute to synovial inflammation in rheumatoid arthritis (RA). In …

Objectives Several clinical studies have suggested the adipocytokine adiponectin is
involved in the progression of rheumatoid arthritis (RA). From this point of view, adiponectin …

The pseudo-tumoral expansion of fibroblast-like synoviocytes is a hallmark of rheumatoid
arthritis (RA), and targeting rheumatoid arthritis fibroblast-like synoviocytes (RAFLSs) may …

Fibroblast-like synoviocytes (FLSs) are one of the main contributors of prostaglandin E2
(PGE2) in the hyperplastic synovium of rheumatoid arthritis (RA) patients. cyclooxygenase-2 …

A key feature of granulomatosis with polyangiitis (GPA; or Wegener's granulomatosis) is the
granulomatous inflammation of the upper respiratory tract, which leads to the subsequent …

Objective T cell protein tyrosine phosphatase (TC‐PTP) is an important regulator of
hematopoiesis and cytokine signaling. Recently, several genome‐wide association studies …