The Cryptococcus neoformans capsule: a sword and a shield

TR O'Meara, JA Alspaugh - Clinical microbiology reviews, 2012 - Am Soc Microbiol
The human fungal pathogen Cryptococcus neoformans is characterized by its ability to
induce a distinct polysaccharide capsule in response to a number of host-specific …

Molecular mechanisms of cryptococcal meningitis

TB Liu, DS Perlin, C Xue - Virulence, 2012 - Taylor & Francis
Fungal meningitis is a serious disease caused by a fungal infection of the central nervous
system (CNS) mostly in individuals with immune system deficiencies. Fungal meningitis is …

Titan cells confer protection from phagocytosis in Cryptococcus neoformans infections

LH Okagaki, K Nielsen - Eukaryotic cell, 2012 - Am Soc Microbiol
The human fungal pathogen Cryptococcus neoformans produces an enlarged “titan” cell
morphology when exposed to the host pulmonary environment. Titan cells exhibit traits that …

Titan cell production enhances the virulence of Cryptococcus neoformans

JN Crabtree, LH Okagaki, DL Wiesner… - Infection and …, 2012 - Am Soc Microbiol
Infection with Cryptococcus neoformans begins when desiccated yeast cells or spores are
inhaled and lodge in the alveoli of the lungs. A subset of cryptococcal cells in the lungs …

Protein kinase A and fungal virulence: a sinister side to a conserved nutrient sensing pathway

KK Fuller, JC Rhodes - Virulence, 2012 - Taylor & Francis
Diverse fungal species are the cause of devastating agricultural and human diseases. As
successful pathogenesis is dependent upon the ability of the fungus to adapt to the …

Regulated expression of cyclic AMP‐dependent protein kinase A reveals an influence on cell size and the secretion of virulence factors in Cryptococcus neoformans

J Choi, AW Vogl, JW Kronstad - Molecular microbiology, 2012 - Wiley Online Library
Cyclic AMP‐dependent protein kinase A (PKA) regulates elaboration of the virulence factors
melanin and polysaccharide capsule in Cryptococcus neoformans. A mutation in PKA1 …

[HTML][HTML] Identification of Genes from the Fungal Pathogen Cryptococcus neoformans Related to Transmigration into the Central Nervous System

HK Tseng, CP Liu, MS Price, AY Jong, JC Chang… - 2012 - journals.plos.org
Background A mouse brain transmigration assessment (MBTA) was created to investigate
the central nervous system (CNS) pathogenesis of cryptococcal meningoencephalitis …

cis- and trans-Acting Localization Determinants of pH Response Regulator Rim13 in Saccharomyces cerevisiae

S Subramanian, CA Woolford, JV Desai, F Lanni… - Eukaryotic …, 2012 - Am Soc Microbiol
ABSTRACT The Rim101/PacC pathway governs adaptation to alkaline pH in many fungi.
Output of the pathway is mediated by transcription factors of the Rim101/PacC family, which …

[PDF][PDF] 隐球菌形态学变化及其致病机制

潘搏, 陈敏, 潘炜华, 廖万清 - 微生物与感染, 2012 - jmi.fudan.edu.cn
摘要致病E 菌在与宿主相互作用过程中可能发生形态学变化# 如菌0 形成1
这种形态学变化有利于病原菌适应不同的外界环境# 使其在宿主体内生存1 外有 …

Know your enemy: how to build and vanquish a global fungal scourge

X Wang, W Li, S Sun, L Kozubowski, SC Lee… - Mycopathologia, 2012 - Springer
Abstract The 8th International Conference on Cryptococcus and Cryptococcosis, chaired by
Maurizio Del Poeta (Medical University of South Carolina), and organized together with …