Abstract The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by
genetic alterations in upstream signaling molecules such as receptor tyrosine kinases …

The Akt family of serine/threonine protein kinases are key regulators of multiple aspects of
cell behaviour, including proliferation, survival, metabolism, and tumorigenesis. Growth …

Melanomas and other cancers that do not express argininosuccinate synthetase (AS), the
rate-limiting enzyme for arginine biosynthesis, are sensitive to arginine depletion with …

The discovery and optimization of a series of 6, 7-dihydro-5 H-cyclopenta [d] pyrimidine
compounds that are ATP-competitive, selective inhibitors of protein kinase B/Akt is reported …

The protein serine-threonine kinase Akt undergoes a substantial conformational change
upon activation, which is induced by the phosphorylation of two critical regulatory residues …

The protein kinase v-akt murine thymoma viral oncogene homolog (AKT), a key regulator of
cell survival and proliferation, is frequently hyperactivated in human cancers. Intramolecular …

Background: This study assessed the safety, tolerability, pharmacokinetics and
pharmacodynamics of the first-in-class dual mammalian target of rapamycin complex …

Periostin (PN) is mainly produced from stromal fibroblasts in cholangiocarcinoma (CCA) and
shows strong impact in cancer promotion. This work aimed to investigate the mechanism …

Platelet-derived growth factor (PDGF) and its receptor are known to be substantially
elevated in lung tissues and pulmonary arterial smooth muscle cells (PASMC) isolated from …

Background Due to the frequent dysregulation of the PI3K/AKT/mTOR signaling pathway,
mTOR represents a suitable therapeutic target in hepatocellular carcinoma (HCC). However …