The discovery of RNA interference (RNAi) has excited the scientific field due to its potential
for wide range of therapeutic applications. The pharmacological mediator of RNAi, short …

Recent discovery of RNA interference (RNAi) technology for gene therapy has triggered
explosive research efforts towards development of small interfering RNA (siRNA) as …

Abstract miR-145 is an important repressor of pluripotency in embryonic stem cells and a
tumor suppressor in different cancers. Here, we found that miR-145 is strongly down …

Cholesterol has been used as an effective component of therapeutic delivery systems
because of its ability to cross cellular membranes. Considering this, well-defined copolymers …

Vascular endothelial growth factor (VEGF) is the important angiogenic factor associated with
tumor growth and metastasis in a wide variety of solid tumors. The aim of this study is to …

Cancer chemotherapy is often limited, since more than one molecule is usually involved with
the cancer pathogenesis. A combination of therapeutic drugs would be a promising …

Breast Cancer Resistance Protein (BCRP, ABCG2) is an efflux protein whose aberrant
activity has been linked to multidrug resistance in cancer. Although siRNA delivery to down …

With contributions from experts and pioneers, this book begins with coverage of the
fundamentals, details the supporting technology, and then elucidates their applications in …

An efficient and safe delivery carrier is required for the therapeutic application of siRNA. In
this research, amphiphilic peptides with arginine and valine residues were evaluated as …

Different from commonly used alkylation strategies, PEI25K was modified with rigid, highly
hydrophobic aromatic moieties to develop superior gene vectors with multiple functions …