The cardiovascular system is broadly composed of the heart, which pumps blood, and the
blood vessels, which carry blood to and from tissues of the body. Heart malformations are …

The first genes composing the Polycomb group (PcG) were identified 50 years ago in
Drosophila melanogaster as essential developmental functions that regulate the correct …

Recurrent somatic ASXL1 mutations occur in patients with myelodysplastic syndrome,
myeloproliferative neoplasms, and acute myeloid leukemia, and are associated with …

Summary Polycomb-repressive complex 1 (PRC1) has a central role in the regulation of
heritable gene silencing during differentiation and development. PRC1 recruitment is …

T cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy
driven mainly by oncogenic activation of NOTCH1 signaling. In this study we report the …

Pluripotent cells possess the ability to differentiate into any cell type. Commitment to
differentiate into specific lineages requires strict control of gene expression to coordinate the …

Polycomb group proteins are repressive chromatin modifiers with essential roles in
metazoan development, cellular differentiation and cell fate maintenance. How Polycomb …

Polycomb-group proteins are transcriptional repressors with essential roles in embryonic
development. Polycomb repressive complex 2 (PRC2) contains the methyltransferase …

Epigenetic deregulation at a number of genomic loci is one of the hallmarks of cancer. A role
for some RNA molecules in guiding repressive polycomb complex PRC2 to specific …

Polycomb Repressive Complex (PRC) 1 and PRC2 regulate genes involved in
differentiation and development. However, the mechanism for how PRC1 and PRC2 are …