Extracellular adenosine 5′ triphosphate (ATP) is a widespread cell-to-cell signaling
molecule in the brain, where it activates cell surface P2X and P2Y receptors. P2X receptors …

Abstract ATP-gated P2X receptors are trimeric ion channels that assemble as homo-or
heteromers from seven cloned subunits. Transcripts and/or proteins of P2X subunits have …

The third edition of this monograph continues to have the goal of providing an overview of
current thought about the spinal cord mechanisms that are responsible for sensory …

Evidence for a significant role and impact of purinergic signaling in normal and diseased
airways is now beyond dispute. The present review intends to provide the current state of …

In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists
were sceptical about its validity, largely because ATP was so well established as an …

Extracellular nucleotides induce cellular responses in the central nervous system (CNS)
through the activation of ionotropic P2X and metabotropic P2Y nucleotide receptors …

Ligand-gated ion channels are prototypic oligomeric membrane proteins whose
stoichiometry determines their functional properties and subcellular localization …

Evidence suggesting the involvement of P2X2 and P2X3 in chronic pain has been obtained
mostly from rodent models. Here we show that rodents may be poor predictors of P2X3 …

P2X receptors are ligand‐gated cation channels that mediate many of the extracellular
actions of adenosine 5′‐triphosphate (ATP). The genes encoding seven different P2X …

The cellular effects of purines and pyrimidines are mediated through an extended
superfamily of purinoceptors, which include metabotropic P1 (adenosine) receptors, and P2 …