Chronic alcohol consumption produces painful peripheral neuropathy for which there is no
reliable successful therapy, mainly due to lack of understanding of its pathobiology …

Neuropathic pain is a disease of global burden. Its symptoms include spontaneous and
stimulus-evoked painful sensations. Several maladaptive mechanisms underlying these …

Pain models in animals have shown low predictivity for analgesic efficacy in humans, and
clinical studies are often very confounded, blurring the evaluation. Human experimental pain …

ETHNOPHARMACOLOGICAL RELEVANCE: Salvia officinalis L. has been used as a
traditional herbal medicine for gastric disturbances and inflammatory processes. This study …

The necessity of safe and effective treatments for chronic pain has intensified the search for
new analgesic drugs. In the last few years, members of a closely-related family of ion …

This study reports a pharmacological evaluation of anti-inflammatory and anti-ulcer activities
of carvacrol, a phenolic monoterpene constituent of essential oils produced by oregano and …

Diabetic peripheral neuropathy (DPN) is a common complication of diabetes that is
associated with axonal atrophy, demyelination, blunted regenerative potential, and loss of …

Contemporary studies illustrate that peripheral injuries activate glial components of the
peripheral and central cellular circuitry. The subsequent release of glial stressors or …

Background: Migraine and other headache disorders affect a large percentage of the
population and cause debilitating pain. Activation and sensitization of the trigeminal primary …

Photosynthesis in plants leads to the accumulation of carbohydrates (eg, sugars, starch),
upon which all terrestrial life depends. In most plants, sucrose is the principal carbohydrate …