Synthesis and assembly of fungal melanin

HC Eisenman, A Casadevall - Applied microbiology and biotechnology, 2012 - Springer
Melanin is a unique pigment with myriad functions that is found in all biological kingdoms. It
is multifunctional, providing defense against environmental stresses such as ultraviolet (UV) …

Diverse Lifestyles and Strategies of Plant Pathogenesis Encoded in the Genomes of Eighteen Dothideomycetes Fungi

RA Ohm, N Feau, B Henrissat, CL Schoch… - PLoS …, 2012 - journals.plos.org
The class Dothideomycetes is one of the largest groups of fungi with a high level of
ecological diversity including many plant pathogens infecting a broad range of hosts. Here …

Navigating the fungal polyketide chemical space: from genes to molecules

YH Chooi, Y Tang - The Journal of organic chemistry, 2012 - ACS Publications
The iterative type I polyketide synthases (IPKSs) are central to the biosynthesis of an
enormously diverse array of natural products in fungi. These natural products, known as …

Two Separate Gene Clusters Encode the Biosynthetic Pathway for the Meroterpenoids Austinol and Dehydroaustinol in Aspergillus nidulans

HC Lo, R Entwistle, CJ Guo, M Ahuja… - Journal of the …, 2012 - ACS Publications
Meroterpenoids are a class of fungal natural products that are produced from polyketide and
terpenoid precursors. An understanding of meroterpenoid biosynthesis at the genetic level …

Illuminating the Diversity of Aromatic Polyketide Synthases in Aspergillus nidulans

M Ahuja, YM Chiang, SL Chang… - Journal of the …, 2012 - ACS Publications
Genome sequencing has revealed that fungi have the ability to synthesize many more
natural products (NPs) than are currently known, but methods for obtaining suitable …

Characterization of a silent azaphilone gene cluster from Aspergillus niger ATCC 1015 reveals a hydroxylation-mediated pyran-ring formation

AO Zabala, W Xu, YH Chooi, Y Tang - Chemistry & biology, 2012 - cell.com
Azaphilones are a class of fungal metabolites characterized by a highly oxygenated pyrano-
quinone bicyclic core and exhibiting a broad range of bioactivities. Although widespread …

Identification of gene clusters associated with fusaric acid, fusarin, and perithecial pigment production in Fusarium verticillioides

DW Brown, RAE Butchko, M Busman… - Fungal Genetics and …, 2012 - Elsevier
The genus Fusarium is of concern to agricultural production and food/feed safety because of
its ability to cause crop disease and to produce mycotoxins. Understanding the genetic basis …

ChLae1 and ChVel1 Regulate T-toxin Production, Virulence, Oxidative Stress Response, and Development of the Maize Pathogen Cochliobolus heterostrophus

D Wu, S Oide, N Zhang, MY Choi, BG Turgeon - PLoS pathogens, 2012 - journals.plos.org
LaeA and VeA coordinate secondary metabolism and differentiation in response to light
signals in Aspergillus spp. Their orthologs, ChLae1 and ChVel1, were identified in the maize …

Culturable endophytes of medicinal plants and the genetic basis for their bioactivity

KI Miller, C Qing, DMY Sze, BD Roufogalis, BA Neilan - Microbial Ecology, 2012 - Springer
The bioactive compounds of medicinal plants are products of the plant itself or of
endophytes living inside the plant. Endophytes isolated from eight different anticancer plants …

Lae1 regulates expression of multiple secondary metabolite gene clusters in Fusarium verticillioides

RAE Butchko, DW Brown, M Busman… - Fungal Genetics and …, 2012 - Elsevier
The filamentous fungus Fusarium verticillioides can cause disease of maize and is capable
of producing fumonisins, a family of toxic secondary metabolites linked to esophageal …