Post-translational modification of proteins by the lipid palmitate is critical for protein
localization and function. Palmitoylation is regulated by the opposing enzymes palmitoyl …

Huntington disease (HD) is a devastating neurodegenerative disease that derives from CAG
repeat expansion in the huntingtin gene. The clinical syndrome consists of progressive …

The development of animal models of Huntington disease (HD) has enabled studies that
help define the molecular aberrations underlying the disease. The BACHD and YAC128 …

There is morphological evidence for differential alterations in striatal medium-sized spiny
neurons (MSNs) giving rise to the direct and indirect output pathways in Huntington's …

Polyglutamine (polyQ) disorders share many similarities, such as a common mutation type in
unrelated human causative genes, neurological character, and certain aspects of …

People with HD have a demonstrated early extra-dimensional set-shifting deficit. In the
present study, we use a novel water T-maze set-shifting procedure and demonstrate its …

Excitotoxic injury to striatum by dysfunctional cortical input or aberrant glutamate uptake may
contribute to Huntington's disease (HD) pathogenesis. Since corticostriatal terminals …

Huntington's disease (HD) is a progressive neurodegenerative disease caused by the
insertion of an expanded polyglutamine sequence within the huntingtin protein. This …

Huntington disease (HD) is one of several fatal neurodegenerative disorders associated
with misfolded proteins. Here, we report a novel method for the sensitive detection of …

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by an
expansion of CAG repeats in the Htt gene. Examination of the post-mortem brains of HD …