MicroRNAs in liver disease

XW Wang, NHH Heegaard, H Ørum - Gastroenterology, 2012 - Elsevier
MicroRNAs are small noncoding RNA molecules that regulate gene expression
posttranscriptionally through complementary base pairing with thousands of messenger …

Endothelial dysfunction in the regulation of cirrhosis and portal hypertension

Y Iwakiri - Liver international, 2012 - Wiley Online Library
Portal hypertension is caused by an increased intrahepatic resistance, a major
consequence of cirrhosis. Endothelial dysfunction in liver sinusoidal endothelial cells …

[PDF][PDF] Adenosine triphosphate‐binding cassette transporter genes up‐regulation in untreated hepatocellular carcinoma is mediated by cellular microRNAs

F Borel, R Han, A Visser, H Petry… - …, 2012 - Wiley Online Library
Adenosine triphosphate (ATP)‐binding cassette (ABC) transporters are drug efflux pumps
responsible for the multidrug resistance phenotype causing hepatocellular carcinoma (HCC) …

MicroRNA-217 promotes ethanol-induced fat accumulation in hepatocytes by down-regulating SIRT1

H Yin, M Hu, R Zhang, Z Shen, L Flatow… - Journal of Biological …, 2012 - ASBMB
Ethanol-mediated inhibition of hepatic sirtuin 1 (SIRT1) plays a crucial role in the
pathogenesis of alcoholic fatty liver disease. Here, we investigated the underlying …

MicroRNA signature in alcoholic liver disease

S Bala, G Szabo - International journal of hepatology, 2012 - Wiley Online Library
Alcoholic liver disease (ALD) is a major global health problem. Chronic alcohol use results
in inflammation and fatty liver, and in some cases, it leads to fibrosis and cirrhosis or …

Environmental exposures, epigenetics and cardiovascular disease

A Baccarelli, S Ghosh - Current Opinion in Clinical Nutrition & …, 2012 - journals.lww.com
Environmental exposures, epigenetics and cardiovascular dise... : Current Opinion in
Clinical Nutrition & Metabolic Care Environmental exposures, epigenetics and …

MicroRNA-1 inhibits proliferation of hepatocarcinoma cells by targeting endothelin-1

D Li, P Yang, H Li, P Cheng, L Zhang, D Wei, X Su… - Life sciences, 2012 - Elsevier
AIMS: MicroRNA-1 (miR-1) has been demonstrated as a tumor-suppressive miRNA, which
shows a down-regulated pattern in several human malignancies including hepatocellular …

[HTML][HTML] MicroRNAs: Small but amazing, and their association with endothelin

M von Brandenstein, C Richter, JWU Fries - Life sciences, 2012 - Elsevier
MicroRNAs (miRNAs) are small non-coding RNA molecules involved in the expressional
regulation of genes by inhibiting gene translation. MicroRNAs are recruited and …

OxymiRs in cutaneous development, wound repair and regeneration

CK Sen, S Roy - Seminars in cell & developmental biology, 2012 - Elsevier
The state of tissue oxygenation is widely recognized as a major microenvironmental cue that
is known to regulate the expression of coding genes. Recent works have extended that …

Hypoxia-inducible factor-1α inhibition by a pyrrolopyrazine metabolite of oltipraz as a consequence of microRNAs 199a-5p and 20a induction

SG Kang, WH Lee, YH Lee, YS Lee, SG Kim - Carcinogenesis, 2012 - academic.oup.com
Oltipraz, a cancer chemopreventive agent, has antitumor and antiangiogenic effects. In
animal models and clinical studies, a considerable amount of oltipraz is metabolized to …