The discovery of the myofibroblast has opened new perspectives for the comprehension of
the biological mechanisms involved in wound healing and fibrotic diseases. In recent years …

Pulmonary fibrosis occurs in a variety of clinical settings, constitutes a major cause of
morbidity and mortality, and represents an enormous unmet medical need. However, the …

Syndecan-1 is a cell surface heparan sulfate proteoglycan that binds to many mediators of
disease pathogenesis. Through these molecular interactions, syndecan-1 can modulate …

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and usually fatal form of
interstitial lung disease (ILD). The precise molecular mechanisms of IPF remain poorly …

Current macrophage phenotype classifications are based on distinct in vitro culture
conditions that do not adequately mirror complex tissue environments. In vivo monocyte …

The molecular mechanisms of acute lung injury are incompletely understood. MicroRNAs
(miRNAs) are crucial biological regulators that act by suppressing their target genes and are …

Most tissues harbor resident mononuclear phagocytes, that is, dendritic cells and
macrophages. A classification that sufficiently covers their phenotypic heterogeneity and …

Aberrant wound healing responses to lung injury are believed to contribute to fibrotic lung
diseases, such as idiopathic pulmonary fibrosis (IPF). The lysophospholipids …

Proteoglycans (PGs) and their associated glycosaminoglycan side chains are effectors of
inflammation, but little is known about changes to the composition of PGs in response to …

Extracellular matrix deposition and tissue scarring characterize the process of fibrosis.
Transforming growth factor beta (TGFβ) and Insulin-like growth factor binding protein-3 …