Cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate were discovered> 2
decades ago. That they are second messengers for mobilizing Ca 2+ stores has since been …

Mammalian two-pore channel proteins (TPC1, TPC2; TPCN1, TPCN2) encode ion channels
in intracellular endosomes and lysosomes and were proposed to mediate endolysosomal …

Mutations in the leucine-rich repeat kinase-2 (LRRK2) gene cause late-onset Parkinson's
disease, but its physiological function has remained largely unknown. Here we report that …

To analyze the copper-induced cross talk among calcium, nitric oxide (NO), and hydrogen
peroxide (H2O2) and the calcium-dependent activation of gene expression, the marine alga …

Summary A cytotoxic T lymphocyte (CTL) kills an infected or tumorigenic cell by Ca 2+-
dependent exocytosis of cytolytic granules at the immunological synapse formed between …

It is not uncommon in drug discovery that the core fragment, typically called scaffold, of a
molecule with an interesting biological activity cannot be developed further because of …

One of the initial steps of modern drug discovery is the identification of small organic
molecules able to inhibit a target macromolecule of therapeutic interest. A small proportion …

Insulin stimulates glucose uptake through the membrane translocation of GLUT4 and
GLUT1. Peroxisome proliferator-activated receptor γ (PPARγ) enhances insulin sensitivity …

Enoyl-acyl carrier protein (ACP) reductase, FabI, is a key enzyme in the bacterial fatty acid
biosynthesis pathway (FAS II). FabI is an NADH-dependent oxidoreductase that acts to …

Background There has been great interest in determining whether natural products show
biological activity toward protein targets of pharmacological relevance. One target of …