The induction of drug-metabolizing enzymes is a special case of pharmacokinetic
interactions with consequences for the concurrent drug therapy. The most important …

Abstract CYP1A1 (cytochrome P4501A1) catalyze the conversion of polycyclic aromatic
hydrocarbons into reactive metabolites, which may induce DNA damage. We hypothesized …

[Frontiers in Bioscience S4, 1539-1546, June 1, 2012] 1539 Cytochrome P450 in non-small
cell lung cancer related to exogenous ch Page 1 [Frontiers in Bioscience S4, 1539-1546, June …

The aryl hydrocarbon receptor (AhR), a ligand-activated member of the basic helix-loop-
helix family of transcription factors, plays a significant role in polycyclic aromatic …

Evidence suggests possible Parkinson's disease (PD)–relevant neural effects of exposure to
polychlorinated biphenyls. Limited epidemiological evidence suggests that polychlorinated …

Below a certain age protocols in pediatric oncology on cytostatic drug therapy advise use, of
other parameters such as weight for dosing; this instead of the most conventional parameter …

Co-contamination with complex mixtures of heavy metals, such as lead (Pb2+) and
halogenated aromatic hydrocarbons (HAHs), such as 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin …

Background A thymine/cytosine point mutation in the MSP I restriction site of cytochrome
P450 1A1 (CYP1A1) has been linked to susceptibility to smoking-related cancers and is …

Sudan dyes possess a high affinity to the aryl hydrocarbon receptor (AHR) and potently
induce its target genes, such as cytochrome P450 (CYP) 1A1, through unknown …

The transgenic Arabidopsis plant XgD2V11-6 carrying the recombinant guinea pig (g) aryl
hydrocarbon receptor (AhR)-mediated β-glucuronidase (GUS) reporter gene expression …