Colorectal cancer (CRC) that demonstrates microsatellite instability (MSI) is caused by either
germline mismatch repair (MMR) gene mutations, or 'sporadic'somatic tumour MLH1 …

Risk prediction models are important to identify individuals at high risk of developing the
disease who can then be offered individually tailored clinical management, targeted …

Purpose To determine whether cancer risks for carriers and noncarriers from families with a
mismatch repair (MMR) gene mutation are increased above the risks of the general …

Background Lynch syndrome is a highly penetrant cancer predisposition syndrome caused
by germline mutations in DNA mismatch repair (MMR) genes. We estimated the risks of …

Identifying individuals who have Lynch syndrome (LS) involves a complex diagnostic work
up that includes taking a detailed family history and a combination of various genetic and …

Lynch syndrome is the most common cause of inherited colorectal cancer, accounting for
approximately 3% of all colorectal cancer cases in the United States. In 2009, an evidence …

Approximately 1 in every 4 to 5 women with a diagnosis of ovarian cancer has a hereditary
gene mutation that is responsible for the development of her cancer. Identifying women at …

The familial cancer syndrome referred to as Lynch I and II was renamed hereditary
nonpolyposis colorectal cancer (HNPCC) only to revert later to Lynch syndrome (LS). LS is …

This review article discusses hereditary cancer predisposition syndromes with uterine
manifestations. Lynch syndrome accounts for 2% to 3% of endometrial cancers. The …

Heterozygous PMS2 germline mutations are associated with Lynch syndrome. Up to one
third of these mutations are genomic deletions. Their detection is complicated by a …