Osteoarthritis (OA), the most common musculoskeletal disorder, is complex, multifaceted,
and characterized by degradation of articular cartilage and alterations in other joint tissues …

Autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, multiple
sclerosis and inflammatory bowel disease, have complex pathogeneses and likely …

Multiple proven and potential risk factors for the development of rheumatoid arthritis (RA)
have been identified, and represent interactions between genes and the environment …

RA is a debilitating disorder that manifests as chronic localized synovial and systemic
inflammation leading to progressive joint destruction. Recent advances in the molecular …

Resident cells, such as fibroblast-like synoviocytes (FLS), play a crucial role in rheumatoid
arthritis (RA). They are implicated in the inflammatory response and play a key role in …

MicroRNAs (miRNAs) are small, noncoding RNAs that regulate gene and protein
expression. miRNAs are critical to a normal immune response and have altered expression …

Rheumatoid arthritis (RA) is a systemic, inflammatory, autoimmune disorder with progressive
articular damage that may result in lifelong disability. Although major strides in …

Objective To identify novel microRNA (miR) associations in synovial fibroblasts (SF), by
performing miR expression profiling on cells isolated from the human tumour necrosis factor …

Objective Global DNA hypomethylation in rheumatoid arthritis synovial fibroblasts (RASFs)
contributes to their intrinsic activation. The aim of this study was to investigate whether …

Objective Cyclooxygenase-2 (COX-2) expression is associated with the pathogenesis of
chronic inflammation and pain in osteoarthritis (OA). A study was undertaken to determine …