DNA methylation represents a form of genome annotation that mediates gene repression by
serving as a maintainable mark that can be used to reconstruct silent chromatin following …

Abstract Changes in gene expression that reset a cell program from a normal to a diseased
state involve multiple genetic circuitries, creating a characteristic signature of gene …

Contemporary views on the structure and function of chromatin are presented and the
history of the development of these ideas as well as the nature of the nucleic acid and …

Szyf M. The early‐life social environment and DNA methylation. DNA methylation is a
chemical modification of DNA that confers, upon identical sequences, different identities that …

During the past few decades we have witnessed an era of remarkable growth in the field of
molecular biology. In 1950 very little was known of the chemical constitution of biological …

In 1977 I wrote a grant proposal in which I applied to study developmental patterns in
enzymatic methylation of DNA in eukaryotes. One part of the proposal was to assay cells at …

Z-DNA, an active element in genome, has drawn intense interest in chemical and biological
field. Its dynamic and transient state makes it challenging to target and regulate. Thus …

DNA methylation is an enzymatic modification of the DNA molecule that confers unique
differential identities upon similar DNA sequences. DNA methylation plays a critical role in …

Epigenetic modifications to DNA and its associated histoneproteins are major influences on
gene expression. This regulatory process is disrupted in cancer and a range of chronic …

The prospect that non-genotoxic environmental exposures of a physical, chemical, or social
nature act on epigenetic mechanisms opens a new field in toxicology. Epigenetics refers to …