Epigenetics and autoimmune diseases
P Quintero-Ronderos, G Montoya-Ortiz - Autoimmune diseases, 2012 - Wiley Online Library
Epigenetics is defined as the study of all inheritable and potentially reversible changes in
genome function that do not alter the nucleotide sequence within the DNA. Epigenetic …
genome function that do not alter the nucleotide sequence within the DNA. Epigenetic …
Lung eQTLs to help reveal the molecular underpinnings of asthma
Genome-wide association studies (GWAS) have identified loci reproducibly associated with
pulmonary diseases; however, the molecular mechanism underlying these associations are …
pulmonary diseases; however, the molecular mechanism underlying these associations are …
Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression
It is known that genetic variants can affect gene expression, but it is not yet completely clear
through what mechanisms genetic variation mediate this expression. We therefore …
through what mechanisms genetic variation mediate this expression. We therefore …
Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases
X Li, EJ Ampleford, TD Howard, WC Moore… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: Genome-wide association studies (GWASs) of asthma have consistently
implicated the ORM1-like 3 and gasdermin B (ORMDL3-GSDMB), IL33, IL-1 receptor–like 1 …
implicated the ORM1-like 3 and gasdermin B (ORMDL3-GSDMB), IL33, IL-1 receptor–like 1 …
Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network
White blood cell count (WBC) is unique among identified inflammatory predictors of chronic
disease in that it is routinely measured in asymptomatic patients in the course of routine …
disease in that it is routinely measured in asymptomatic patients in the course of routine …
[PDF][PDF] Respiratory medicine–genetic base for allergy and asthma
A Binia, M Kabesch - Swiss medical weekly, 2012 - smw.ch
Allergy and asthma are complex diseases influenced by many genes and molecular
mechanisms. Recently a number of genome-wide association studies (GWAS) have …
mechanisms. Recently a number of genome-wide association studies (GWAS) have …
Sex-biased genetic effects on gene regulation in humans
AS Dimas, AC Nica, SB Montgomery… - Genome …, 2012 - genome.cshlp.org
Human regulatory variation, reported as expression quantitative trait loci (eQTLs),
contributes to differences between populations and tissues. The contribution of eQTLs to …
contributes to differences between populations and tissues. The contribution of eQTLs to …
[PDF][PDF] Use of a multiethnic approach to identify rheumatoid-arthritis-susceptibility loci, 1p36 and 17q12
We have previously shown that rheumatoid arthritis (RA) risk alleles overlap between
different ethnic groups. Here, we utilize a multiethnic approach to show that we can …
different ethnic groups. Here, we utilize a multiethnic approach to show that we can …
Interaction between genetic and epigenetic variation defines gene expression patterns at the asthma-associated locus 17q12-q21 in lymphoblastoid cell lines
S Berlivet, S Moussette, M Ouimet, DJ Verlaan, V Koka… - Human genetics, 2012 - Springer
Phenotypic variation results from variation in gene expression, which is modulated by
genetic and/or epigenetic factors. To understand the molecular basis of human disease …
genetic and/or epigenetic factors. To understand the molecular basis of human disease …
17q12-21 variants are associated with asthma and interact with active smoking in an adult population from the United Kingdom
S Marinho, A Custovic, P Marsden, JA Smith… - Annals of Allergy …, 2012 - Elsevier
BACKGROUND: Although an association between 17q12-21 and asthma has been
replicated across different populations, some inconsistencies have been found between …
replicated across different populations, some inconsistencies have been found between …