Heparan sulfate biosynthesis: regulation and variability
Nearly all vertebrate cells have been shown to express heparan sulfate proteoglycans
(HSPGs) at the cell surface. The HSPGs bind to many secreted signaling proteins, including …
(HSPGs) at the cell surface. The HSPGs bind to many secreted signaling proteins, including …
An introduction to proteoglycans and their localization
JR Couchman, CA Pataki - Journal of Histochemistry & …, 2012 - journals.sagepub.com
Proteoglycans comprise a core protein to which one or more glycosaminoglycan chains are
covalently attached. Although a small number of proteins have the capacity to be glycanated …
covalently attached. Although a small number of proteins have the capacity to be glycanated …
Syndecan–syntenin–ALIX regulates the biogenesis of exosomes
MF Baietti, Z Zhang, E Mortier, A Melchior… - Nature cell …, 2012 - nature.com
The biogenesis of exosomes, small secreted vesicles involved in signalling processes,
remains incompletely understood. Here, we report evidence that the syndecan heparan …
remains incompletely understood. Here, we report evidence that the syndecan heparan …
Signaling in cell differentiation and morphogenesis
MA Basson - Cold Spring Harbor perspectives in biology, 2012 - cshperspectives.cshlp.org
All the information to make a complete, fully functional living organism is encoded within the
genome of the fertilized oocyte. How is this genetic code translated into the vast array of …
genome of the fertilized oocyte. How is this genetic code translated into the vast array of …
Transport of fibroblast growth factor 2 in the pericellular matrix is controlled by the spatial distribution of its binding sites in heparan sulfate
L Duchesne, V Octeau, RN Bearon, A Beckett… - PLoS …, 2012 - journals.plos.org
The heparan sulfate (HS) chains of proteoglycans are a key regulatory component of the
extracellular matrices of animal cells, including the pericellular matrix around the plasma …
extracellular matrices of animal cells, including the pericellular matrix around the plasma …
Proteoglycan sequence
Proteoglycans (PGs) are among the most structurally complex biomacromolecules in nature.
They are present in all animal cells and frequently exert their critical biological functions …
They are present in all animal cells and frequently exert their critical biological functions …
Structure of the activating IL-1 receptor signaling complex
Abstract Interleukin-1 (IL-1)-family cytokines are mediators of innate and adaptive immunity.
They exert proinflammatory effects by binding a primary receptor that recruits a receptor …
They exert proinflammatory effects by binding a primary receptor that recruits a receptor …
Growth factor binding on heparin mimetic peptide nanofibers
Immobilization of growth factors in scaffolds is important for controlling their dose and
bioactivity for regenerative medicine applications. Although numerous covalent and …
bioactivity for regenerative medicine applications. Although numerous covalent and …
Fucanomics and galactanomics: Current status in drug discovery, mechanisms of action and role of the well-defined structures
VH Pomin - Biochimica et Biophysica Acta (BBA)-General Subjects, 2012 - Elsevier
BACKGROUND: With the recent advent of glycomics, many medically relevant glycans have
been discovered. Sulfated fucans (SFs) and sulfated galactans (SGs) are one of these …
been discovered. Sulfated fucans (SFs) and sulfated galactans (SGs) are one of these …
Novel regulation of fibroblast growth factor 2 (FGF2)-mediated cell growth by polysialic acid
S Ono, M Hane, K Kitajima, C Sato - Journal of Biological Chemistry, 2012 - ASBMB
Polysialic acid (polySia) is a unique polysaccharide that modifies neural cell adhesion
molecule (NCAM) spatiotemporally. Recently, we demonstrated that polySia functions as a …
molecule (NCAM) spatiotemporally. Recently, we demonstrated that polySia functions as a …