Redox modulation of the DNA damage response
F Caputo, R Vegliante, L Ghibelli - Biochemical pharmacology, 2012 - Elsevier
Lesions to DNA trigger the DNA-damage response (DDR), a complex, multi-branched cell-
intrinsic process targeted to DNA repair, or elimination of the damaged cells by apoptosis …
intrinsic process targeted to DNA repair, or elimination of the damaged cells by apoptosis …
Genetic Screening for Synthetic Lethal Partners of Polynucleotide Kinase/Phosphatase: Potential for Targeting SHP-1–Depleted Cancers
TR Mereniuk, RA Maranchuk, A Schindler… - Cancer research, 2012 - AACR
A genetic screen using a library of 6,961 siRNAs led to the identification of SHP-1 (PTPN6),
a tumor suppressor frequently mutated in malignant lymphomas, leukemias, and prostate …
a tumor suppressor frequently mutated in malignant lymphomas, leukemias, and prostate …
[HTML][HTML] Radioprotective potential of histamine on rat small intestine and uterus
E Carabajal, N Massari, M Croci… - European journal of …, 2012 - ncbi.nlm.nih.gov
The aim of this study was to improve knowledge about histamine radioprotective potential
investigating its effect on reducing ionising radiation-induced injury and genotoxic damage …
investigating its effect on reducing ionising radiation-induced injury and genotoxic damage …
Amifostine and the endogenous cellular antioxidant enzyme manganese superoxide dismutase in radioprotection
JS Murley, Y Kataoka, DJ Grdina - Oxidative Stress in Cancer Biology and …, 2012 - Springer
Amifostine is currently the only drug approved by the US Food and Drug Administration for
use as a radiation protector in the clinical treatment of cancer. While its approved use is …
use as a radiation protector in the clinical treatment of cancer. While its approved use is …
[引用][C] Botanical Extracts as Medical Countermeasures for Radiation Induced DNA Damage
EK Kennedy, LP Lalonde, R Liu, BC Foster… - 2012