Osteoporosis is among the most common and costly diseases and is increasing in
prevalence owing to the ageing of our global population. Clinically defined largely through …

Osteoporosis is defined as low bone mineral density associated with skeletal fractures
secondary to minimal or no trauma, most often involving the spine, the hip, and the forearm …

Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed
the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 …

Age-related changes in DNA methylation have been implicated in cellular senescence and
longevity, yet the causes and functional consequences of these variants remain unclear. To …

We aimed to identify genetic variants associated with cortical bone thickness (CBT) and
bone mineral density (BMD) by performing two separate genome-wide association study …

Hip osteoarthritis (HOA) is one of the most disabling and common joint disorders with a large
genetic component that is, however, still ill-defined. To date, genome-wide association …

Context: The primary goals of genome-wide association studies (GWAS) are to discover new
molecular and biological pathways involved in the regulation of bone metabolism that can …

Aims/hypothesis In this study we aimed to replicate the previously reported association
between the glycaemic response to metformin and the SNP rs11212617 at a locus that …

The role of rare genetic variation in the etiology of complex disease remains unclear.
However, the development of next-generation sequencing technologies offers the …

Osteoporosis is a common polygenic disease and global healthcare priority but its genetic
basis remains largely unknown. We report a high-throughput multi-parameter phenotype …