Cancer stem cells as a predictive factor in radiotherapy
TB Brunner, LA Kunz-Schughart… - Seminars in radiation …, 2012 - Elsevier
Cancer stem cell research is one of the most thriving and competitive areas in oncology
research because it has the potential to dramatically affect clinical outcomes. Led by …
research because it has the potential to dramatically affect clinical outcomes. Led by …
Immunomodulatory effects of antimicrobial agents. Part I: antibacterial and antiviral agents
MT Labro - Expert Review of Anti-infective Therapy, 2012 - Taylor & Francis
Despite impressive therapeutic progresses in the battle against infections, microorganisms
are still a threat to mankind. With hundreds of antibacterial molecules, major concerns …
are still a threat to mankind. With hundreds of antibacterial molecules, major concerns …
Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir
Background Human epidermal growth factor receptor 2 (HER2)–positive breast cancer is
highly aggressive and has higher risk of recurrence than HER2-negative cancer. With few …
highly aggressive and has higher risk of recurrence than HER2-negative cancer. With few …
[HTML][HTML] A phase I trial of the HIV protease inhibitor nelfinavir with concurrent chemoradiotherapy for unresectable stage IIIA/IIIB non-small cell lung cancer: a report of …
R Rengan, R Mick, D Pryma, MA Rosen, LL Lin… - Journal of Thoracic …, 2012 - Elsevier
Background The objective of this phase I trial was to determine dose-limiting toxicities (DLT)
and the maximally tolerated dose of the radiosensitizer Nelfinavir in combination with …
and the maximally tolerated dose of the radiosensitizer Nelfinavir in combination with …
Treatment of locally advanced pancreatic cancer: the role of radiation therapy
K Johung, MW Saif, BW Chang - International Journal of Radiation …, 2012 - Elsevier
Pancreatic cancer remains associated with an extremely poor prognosis. Surgical resection
can be curative, but the majority of patients present with locally advanced or metastatic …
can be curative, but the majority of patients present with locally advanced or metastatic …
Phase I study of nelfinavir in liposarcoma
J Pan, M Mott, B Xi, E Hepner, M Guan… - Cancer chemotherapy …, 2012 - Springer
Purpose HIV protease inhibitors are associated with HIV protease inhibitor–related
lipodystrophy syndrome. We hypothesized that liposarcomas would be similarly susceptible …
lipodystrophy syndrome. We hypothesized that liposarcomas would be similarly susceptible …
Potential therapeutic approaches for modulating expression and accumulation of defective lamin A in laminopathies and age-related diseases
A Zhavoronkov, Z Smit-McBride, KJ Guinan… - Journal of molecular …, 2012 - Springer
Scientific understanding of the genetic components of aging has increased in recent years,
with several genes being identified as playing roles in the aging process and, potentially …
with several genes being identified as playing roles in the aging process and, potentially …
Associations between HIV and human pathways revealed by protein-protein interactions and correlated gene expression profiles
KC Chen, TY Wang, C Chan - PLoS One, 2012 - journals.plos.org
Background AIDS is one of the most devastating diseases in human history. Decades of
studies have revealed host factors required for HIV infection, indicating that HIV exploits host …
studies have revealed host factors required for HIV infection, indicating that HIV exploits host …
The HIV-1 protease inhibitor nelfinavir activates PP2 and inhibits MAPK signaling in macrophages: a pathway to reduce inflammation
MA Wallet, CM Reist, JC Williams… - Journal of leukocyte …, 2012 - academic.oup.com
Nelfinavir has anti-inflammatory effects directly upon human macrophages independent of
antiviral activity. The HIV-1 PI NFV has off-target effects upon host enzymes, including …
antiviral activity. The HIV-1 PI NFV has off-target effects upon host enzymes, including …
3D tumour spheroids as a model to assess the suitability of [18F] FDG-PET as an early indicator of response to PI3K inhibition
CJ Kelly, K Hussien, RJ Muschel - Nuclear medicine and biology, 2012 - Elsevier
BACKGROUND:[18F] Fluorodeoxyglucose Positron Emission Tomography ([18F] FDG-PET)
is widely used to monitor response to therapy in the clinic and has, more recently, been …
is widely used to monitor response to therapy in the clinic and has, more recently, been …