Comparative effectiveness research in oncology methodology: observational data

DL Hershman, JD Wright - Journal of clinical oncology, 2012 - ascopubs.org
The goal of comparative effectiveness research is to inform clinical decisions between
alternate treatment strategies using data that reflect real patient populations and real-world …

[HTML][HTML] Regulatory pathways associated with bone loss and bone marrow adiposity caused by aging, chemotherapy, glucocorticoid therapy and radiotherapy

KR Georgiou, SK Hui, CJ Xian - American journal of stem cells, 2012 - ncbi.nlm.nih.gov
The bone marrow is a complex environment that houses haematopoietic and mesenchymal
cell populations and regulates bone turnover throughout life. The high proliferative capacity …

Rectal cancer

AB Benson, T Bekaii-Saab, E Chan, YJ Chen… - Journal of the National …, 2012 - jnccn.org
These NCCN Clinical Practice Guidelines in Oncology provide recommendations for the
management of rectal cancer, beginning with the clinical presentation of the patient to the …

Devastation of adult stem cell pools by irradiation precedes collapse of trabecular bone quality and quantity

DE Green, BJ Adler, ME Chan… - Journal of Bone and …, 2012 - academic.oup.com
Stem cell depletion and compromised bone marrow resulting from radiation exposure
fosters long‐term deterioration of numerous physiologic systems, with the degradation of the …

Twenty-five-year experience with radical chemoradiation for anal cancer

JM Tomaszewski, E Link, T Leong, A Heriot… - International Journal of …, 2012 - Elsevier
PURPOSE: To evaluate the prognostic factors, patterns of failure, and late toxicity in patients
treated with chemoradiation (CRT) for anal cancer. METHODS AND MATERIALS …

Insufficiency fractures after pelvic radiation therapy for uterine cervical cancer: an analysis of subjects in a prospective multi-institutional trial, and cooperative study of …

S Tokumaru, T Toita, M Oguchi, T Ohno, S Kato… - International Journal of …, 2012 - Elsevier
PURPOSE: To investigate pelvic insufficiency fractures (IF) after definitive pelvic radiation
therapy for early-stage uterine cervical cancer, by analyzing subjects of a prospective, multi …

Mesenchymal stem cells show radioresistance in vivo

S Singh, FR Kloss, R Brunauer… - Journal of cellular …, 2012 - Wiley Online Library
Irradiation impacts on the viability and differentiation capacity of tissue‐borne mesenchymal
stem cells (MSC), which play a pivotal role in bone regeneration. As a consequence of …

Low magnitude mechanical signals mitigate osteopenia without compromising longevity in an aged murine model of spontaneous granulosa cell ovarian cancer

GM Pagnotti, BJ Adler, DE Green, ME Chan… - Bone, 2012 - Elsevier
Cancer progression is often paralleled by a decline in bone mass, raising risk of fracture.
Concerns persist regarding anabolic interventions for skeletal protection, as these may …

Provider characteristics, clinical-work processes and their relationship to discharge summary quality for sub-acute care patients

AJH Kind, CT Thorpe, JA Sattin, SE Walz… - Journal of general …, 2012 - Springer
ABSTRACT BACKGROUND Discharge summaries play a pivotal role in the transitional care
of patients discharged to sub-acute care facilities, but the best ways to facilitate document …

The influence of therapeutic radiation on the patterns of bone marrow in ovary-intact and ovariectomized mice

SK Hui, L Sharkey, LS Kidder, Y Zhang, G Fairchild… - 2012 - journals.plos.org
Background The functional components of bone marrow (ie, the hematopoietic and stromal
populations) and the adjacent bone have traditionally been evaluated incompletely as …