Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling
Evidence is accumulating regarding the importance of circadian core oscillators, several
associated factors, and melatonin signaling in the maintenance of health. Dysfunction of …
associated factors, and melatonin signaling in the maintenance of health. Dysfunction of …
Circadian rhythm disruption in cancer biology
C Savvidis, M Koutsilieris - Molecular medicine, 2012 - Springer
Circadian rhythms show universally a 24-h oscillation pattern in metabolic, physiological
and behavioral functions of almost all species. This pattern is due to a fundamental …
and behavioral functions of almost all species. This pattern is due to a fundamental …
The circadian clock gene BMAL1 is a novel therapeutic target for malignant pleural mesothelioma
M Elshazley, M Sato, T Hase… - … Journal of Cancer, 2012 - Wiley Online Library
Malignant pleural mesothelioma (MPM) is a highly aggressive neoplasm arising from the
mesothelial cells lining the parietal pleura and it exhibits poor prognosis. Although there has …
mesothelial cells lining the parietal pleura and it exhibits poor prognosis. Although there has …
miR-10a is aberrantly overexpressed in Nucleophosmin1 mutated acute myeloid leukaemia and its suppression induces cell death
Background Acute myeloid leukaemia (AML) with nucleophosmin-1 (NPM1) mutation is a
major subtype of AML. The NPM1 mutation induces a myeloproliferative disorder, but …
major subtype of AML. The NPM1 mutation induces a myeloproliferative disorder, but …
Functional polymorphisms of circadian positive feedback regulation genes and clinical outcome of Chinese patients with resected colorectal cancer
BACKGROUND: Previous studies have demonstrated that circadian genes play a role in the
development and progression of many cancers. This study aims to assess the effects of …
development and progression of many cancers. This study aims to assess the effects of …
The Circadian Control of Skin and Cutaneous Photodamage†
JA Desotelle, MJ Wilking… - Photochemistry and …, 2012 - Wiley Online Library
Biologically, light including ultraviolet (UV) radiation is vital for life. However, UV exposure
does not come without risk, as it is a major factor in the development of skin cancer. Natural …
does not come without risk, as it is a major factor in the development of skin cancer. Natural …
Circadian clock disruptions and the risk of cancer
T Lahti, I Merikanto, T Partonen - Annals of medicine, 2012 - Taylor & Francis
Disrupted circadian rhythms may lead to failures in the control of the cell division cycle and
the subsequent malignant cell growth. In order to understand the pathogenesis of cancer …
the subsequent malignant cell growth. In order to understand the pathogenesis of cancer …
Health effects of extremely low‐frequency magnetic fields: reconsidering the melatonin hypothesis in the light of current data on magnetoreception
J Vanderstraeten, L Verschaeve… - Journal of Applied …, 2012 - Wiley Online Library
ABSTRACT The so‐called 'Melatonin Hypothesis' proposed that decreased nocturnal
production of melatonin (MLT) might explain the increased risk of breast cancer that has …
production of melatonin (MLT) might explain the increased risk of breast cancer that has …
[HTML][HTML] Modeling SDF-1–induced mobilization in leukemia cell lines
A Zepeda-Moreno, R Saffrich, T Walenda… - Experimental …, 2012 - Elsevier
The stromal cell–derived factor 1 (SDF-1) is essential for circulation, homing, and retention
of hematopoietic stem cells in the bone marrow. Present evidence indicates that this factor …
of hematopoietic stem cells in the bone marrow. Present evidence indicates that this factor …
小鼠外周组织时钟基因启动子区甲基化分析
林庆玲， 蔡彦宁， 袁艳鹏， 左晓虹 - 基础医学与临床, 2012 - journal11.magtechjournal.com
摘要: 目的建立一种简单快速经济的检测八个主要时钟基因BMAL1, BMAL2, CLOCK, NPAS2,
PER1, PER2, CRY1 和CRY2 启动子区甲基化状态的方法. 同时检测小鼠外周组织肝, 心, 肾 …
PER1, PER2, CRY1 和CRY2 启动子区甲基化状态的方法. 同时检测小鼠外周组织肝, 心, 肾 …