Statins, among the most commonly prescribed drugs worldwide, are cholesterol-lowering
agents used to manage and prevent cardiovascular and coronary heart diseases. Recently …

The modern era of antiplatelet therapy was founded by large clinical trials demonstrating the
benefit of aspirin and clopidogrel in the treatment and prevention of acute coronary …

Background—Statins exert an antithrombotic effect in patients at risk of or with acute
thrombosis, but no study has investigated whether this effect is immediate and whether there …

Increased oxidative stress appears to be of fundamental importance in the pathogenesis
and development of several disease processes. Indeed, it is well known that reactive oxygen …

Visceral obesity is characterized by increased risk of cardiovascular disease as well as
higher incidence of malignancies, including colorectal cancer (CRC), although the …

CD40 ligand (CD40L) is a thrombo-inflammatory molecule that predicts cardiovascular
events. Platelets constitute the major source of soluble CD40L (sCD40L), which has been …

Antithrombotic therapy (including antiplatelet and anticoagulant drugs) is the cornerstone of
the current medical treatment of patients with acute coronary syndromes (ACS). This therapy …

3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors are primarily used
to treat dyslipidemia. Yet, these medications have a number of additional important …

The beneficial effects of statin pretreatment as well as of staccato reperfusion (SR) on
myocardium have been demonstrated in patients undergoing cardiac interventions. In this …

Periprocedural statin therapy has been shown to decrease the rate of myocardial infarctions
(MIs) after percutaneous coronary intervention (PCI). However, the impact of long-term statin …