Pharmacological actions of statins: a critical appraisal in the management of cancer
P Gazzerro, MC Proto, G Gangemi, AM Malfitano… - Pharmacological …, 2012 - ASPET
Statins, among the most commonly prescribed drugs worldwide, are cholesterol-lowering
agents used to manage and prevent cardiovascular and coronary heart diseases. Recently …
agents used to manage and prevent cardiovascular and coronary heart diseases. Recently …
Interindividual variability in the efficacy of oral antiplatelet drugs: definitions, mechanisms and clinical importance
M Wurtz, E Lerkevang Grove - Current pharmaceutical design, 2012 - ingentaconnect.com
The modern era of antiplatelet therapy was founded by large clinical trials demonstrating the
benefit of aspirin and clopidogrel in the treatment and prevention of acute coronary …
benefit of aspirin and clopidogrel in the treatment and prevention of acute coronary …
Immediate antioxidant and antiplatelet effect of atorvastatin via inhibition of Nox2
Background—Statins exert an antithrombotic effect in patients at risk of or with acute
thrombosis, but no study has investigated whether this effect is immediate and whether there …
thrombosis, but no study has investigated whether this effect is immediate and whether there …
Platelet function in health and disease: from molecular mechanisms, redox considerations to novel therapeutic opportunities
Increased oxidative stress appears to be of fundamental importance in the pathogenesis
and development of several disease processes. Indeed, it is well known that reactive oxygen …
and development of several disease processes. Indeed, it is well known that reactive oxygen …
Obesity-driven inflammation and colorectal cancer
N Vazzana, S Riondino, V Toto… - Current medicinal …, 2012 - ingentaconnect.com
Visceral obesity is characterized by increased risk of cardiovascular disease as well as
higher incidence of malignancies, including colorectal cancer (CRC), although the …
higher incidence of malignancies, including colorectal cancer (CRC), although the …
Involvement of nuclear factor κB in platelet CD40 signaling
A Hachem, D Yacoub, Y Zaid, W Mourad… - … and biophysical research …, 2012 - Elsevier
CD40 ligand (CD40L) is a thrombo-inflammatory molecule that predicts cardiovascular
events. Platelets constitute the major source of soluble CD40L (sCD40L), which has been …
events. Platelets constitute the major source of soluble CD40L (sCD40L), which has been …
Thrombin generation assay: a new tool to predict and optimize clinical outcome in cardiovascular patients?
G Campo, R Pavasini, A Pollina, L Fileti… - Blood coagulation & …, 2012 - journals.lww.com
Antithrombotic therapy (including antiplatelet and anticoagulant drugs) is the cornerstone of
the current medical treatment of patients with acute coronary syndromes (ACS). This therapy …
the current medical treatment of patients with acute coronary syndromes (ACS). This therapy …
Statin therapy
CG Koch - Current pharmaceutical design, 2012 - ingentaconnect.com
3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors are primarily used
to treat dyslipidemia. Yet, these medications have a number of additional important …
to treat dyslipidemia. Yet, these medications have a number of additional important …
The effect of acute administration of statins on coronary microcirculation during the pre-revascularization period in patients with myocardial infraction
The beneficial effects of statin pretreatment as well as of staccato reperfusion (SR) on
myocardium have been demonstrated in patients undergoing cardiac interventions. In this …
myocardium have been demonstrated in patients undergoing cardiac interventions. In this …
Impact of long-term statin therapy on postprocedural myocardial infarction in patients undergoing nonemergency percutaneous coronary intervention
J Gordin, A Haider, RV Swaminathan, LK Kim… - The American journal of …, 2012 - Elsevier
Periprocedural statin therapy has been shown to decrease the rate of myocardial infarctions
(MIs) after percutaneous coronary intervention (PCI). However, the impact of long-term statin …
(MIs) after percutaneous coronary intervention (PCI). However, the impact of long-term statin …