For all organisms promoting protein homeostasis is a high priority in order to optimize
cellular functions and resources. However, there is accumulating evidence that aging leads …

The non-reducing disaccharide trehalose has been long considered only as a reserve
carbohydrate. However, recent studies in yeast suggested that this osmolyte can protect …

Maintenance of proteome integrity (proteostasis) is essential for cellular and organismal
survival. Various cellular mechanisms work to preserve proteostasis by ensuring correct …

Recently, we reported widespread intraneuronal prion protein (PrP) immunoreactivity in
genetic Creutzfeldt-Jakob disease (CJD) associated with the E200K mutation. Here, we …

Prions are the causative agents of a group of lethal, neurodegenerative conditions that
include sheep scrapie, bovine spongiform encephalopathy (BSE), and human Creutzfeldt …