The perception and endogenous modulation of pain

MH Ossipov - Scientifica, 2012 - Wiley Online Library
Pain is often perceived an unpleasant experience that includes sensory and
emotional/motivational responses. Accordingly, pain serves as a powerful teaching signal …

Are the pharmacology and physiology of α2adrenoceptors determined by α2‐heteroreceptors and autoreceptors respectively?

R Gilsbach, L Hein - British journal of pharmacology, 2012 - Wiley Online Library
α2‐Adrenoceptors are important mediators of physiological responses to the endogenous
catecholamines noradrenaline and adrenaline. In addition, α2‐adrenoceptors are …

Effect of intravenous dexmedetomidine infusion on some proinflammatory cytokines, stress hormones and recovery profile in major abdominal surgery

AG Yacout, HA Osman, MH Abdel-Daem… - Alexandria Journal of …, 2012 - ajol.info
Background: This study was designed to evaluate the effect of intravenous
dexmedetomidine infusion in patients undergoing major abdominal surgery on stress …

Morphine and clonidine synergize to ameliorate low back pain in mice

M Tajerian, M Millecamps… - Pain research and …, 2012 - Wiley Online Library
Chronic low back pain (LBP) is a debilitating condition associated with signs of axial and
radiating pain. In humans with chronic LBP, opioids are often prescribed with varying …

Might the observed α2A-adrenoreceptor agonism or antagonism of allyphenyline analogues be ascribed to different molecular conformations?

E Diamanti, F Del Bello, G Carbonara, A Carrieri… - Bioorganic & medicinal …, 2012 - Elsevier
We recently reported that the α2-adrenoreceptor (AR) ligand allyphenyline (9) significantly
enhanced morphine analgesia (due to its α2C-AR agonism), was devoid of sedative side …

Knockdown of α2C-adrenoceptors in the occipital cortex rescued long-term potentiation in hidden prenatally malnourished rats

R Barra, R Soto-Moyano, L Valladares… - Neurobiology of learning …, 2012 - Elsevier
Moderate reduction in the protein content of the mother's diet calorically compensated by
carbohydrates (the so-called “hidden” prenatal malnutrition) leads to increased neocortical …

Discovery of Selective Alpha2C Adrenergic Receptor Agonists

E Jnoff, B Christophe, P Collart, F Coloretti… - …, 2012 - Wiley Online Library
Neuropathic pain has recently been defined by the International Association for the Study of
Pain (IASP) as “pain caused by a lesion or disease of the somatosensory system”.[1] …

[DOC][DOC] КОНДЕНСИРОВАННЫЕ БЕНЗИМИДАЗОЛЫ–НОВЫЙ КЛАСС КАППА-ОПИОИДНЫХ АГОНИСТОВ 14.03. 06.-фармакология, клиническая фармакология

ОЮ Гречко - Волгоград: Волгоградский государственный …, 2012 - volgmed.ru
Защита состоится «____» ________________2012 г. в _____ ч. на заседании
Диссертационного Совета Д 208.008. 02 при ГБОУ ВПО «Волгоградский …

[PDF][PDF] 3D homology model of the α2C-adrenergic receptor subtype

L Halip, AT Gruia, A Borota, M Mracec… - Rev. Roum …, 2012 - researchgate.net
Comparative modeling of the three-dimensional structure of the human α2C adrenoceptor
(α2C-AR) based on the high-resolution X-ray structure of the human β2-AR (2RH1, PDB file) …

[引用][C] 右美托咪啶应用于区域麻醉的研究进展

杜晓蓉, 曾宪章, 徐咏梅 - 实用医学杂志, 2012