Immunology (1955–1975): The natural selection theory, the Two signal hypothesis and positive repertoire selection

DR Forsdyke - Journal of the History of Biology, 2012 - Springer
Observations suggesting the existence of natural antibody prior to exposure of an organism
to the corresponding antigen, led to the natural selection theory of antibody formation of …

An emerging role for serine protease inhibitors in T lymphocyte immunity and beyond

PG Ashton-Rickardt - International Scholarly Research Notices, 2012 - Wiley Online Library
The serine proteases of T lymphocytes provide immunity to infection. Serine Proteases
Inhibitors (serpins) control the recognition of antigen, effector function, and homeostatic …

[图书][B] Peptide-MHC Heterodimers Reveal Differential Contribution of Weak Self-Peptides to Positive and Negative Selection

J Juang - 2012 - search.proquest.com
T cell central tolerance depends on the T cell receptor's affinity for self peptide/major
histocompatibility complex, but how this affinity translates into the decision to mature or …