Context Mesenchymal stem cells (MSCs) are under evaluation as a therapy for ischemic
cardiomyopathy (ICM). Both autologous and allogeneic MSC therapies are possible; …

Stem cell research has expanded at an exponential rate, but its therapeutic applications
have progressed much more slowly. Currently, the research focuses on understanding …

Although pharmacological and interventional advances have reduced the morbidity and
mortality of ischemic heart disease, there is an ongoing need for novel therapeutic strategies …

On rigid surfaces, the cytoskeleton of migrating cells is polarized, but tissue matrix is
normally soft. We show that nonmuscle MIIB (myosin-IIB) is unpolarized in cells on soft …

Once damaged, cardiac muscle has little intrinsic repair capability due to the poor
regeneration potential of remaining cardiomyocytes. One method of overcoming this issue is …

Bone marrow (BM) and subcutaneous adipose tissue (Ad) are both considered being
prospective sources of MSC for therapeutic applications. However, functional properties and …

Autophagy is a complex “self-eating” process and could be utilized for cell survival under
stresses. Statins, which could reduce apoptosis in mesenchymal stem cells (MSCs) during …

Upon secretion, transforming growth factor β (TGFβ) is maintained in a sequestered state in
extracellular matrix as a latent form. The latent TGFβ is considered as a molecular sensor …

Rationale: Induced pluripotent stem cells (iPSCs) hold great promise for the development of
patient-specific therapies for cardiovascular disease. However, clinical translation will …

Sustainable and reproducible large animal models that closely replicate the clinical
sequelae of myocardial infarction (MI) are important for the translation of basic science …