The genetic bases of neuropsychiatric disorders are beginning to yield to scientific inquiry.
Genome-wide studies of copy number variation (CNV) have given rise to a new …

Serotonin (5-HT) shapes brain networks during development and modulates a wide
spectrum of essential neuronal functions ranging from perception and cognitive appraisal to …

Abstract According to DSM-IV TR and ICD-10, a diagnosis of autism or Asperger Syndrome
precludes a diagnosis of attention-deficit/hyperactivity disorder (ADHD). However, despite …

The human synapse proteome is a highly complex collection of proteins that is disrupted by
hundreds of gene mutations causing over 100 brain diseases. These synaptic diseases, or …

We examined the burden of large, rare, copy-number variants (CNVs) in 192 individuals with
renal hypodysplasia (RHD) and replicated findings in 330 RHD cases from two independent …

There has been a steady retreat by the private sector away from developing medications for
mental disorders. This retreat comes just as research is identifying new molecular targets …

Haplotypes are an important resource for a large number of applications in human genetics,
but computationally inferred haplotypes are subject to switch errors that decrease their utility …

Traf2 and NcK interacting kinase (TNiK) contains serine-threonine kinase and scaffold
domains and has been implicated in cell proliferation and glutamate receptor regulation in …

This article serves to outline a research paradigm to investigate main effects and interactions
of genes, environment, and development on behavior and psychiatric illness. We provide a …

We have identified a rare small (∼ 450 kb unique sequence) recurrent deletion in a
previously linked attention-deficit hyperactivity disorder (ADHD) locus at 2q21. 1 in five …