Pharmacological actions of statins: a critical appraisal in the management of cancer
P Gazzerro, MC Proto, G Gangemi, AM Malfitano… - Pharmacological …, 2012 - ASPET
Statins, among the most commonly prescribed drugs worldwide, are cholesterol-lowering
agents used to manage and prevent cardiovascular and coronary heart diseases. Recently …
agents used to manage and prevent cardiovascular and coronary heart diseases. Recently …
Secreted klotho and chronic kidney disease
MC Hu, M Kuro-o, OW Moe - Endocrine FGFs and Klothos, 2012 - Springer
Soluble Klotho (sKl) in the circulation can be generated directly by alterative splicing of the
Klotho transcript or the extracellular domain of membrane Klotho can be released from …
Klotho transcript or the extracellular domain of membrane Klotho can be released from …
Adipose tissue‐derived mesenchymal stem cells improve revascularization outcomes to restore renal function in swine atherosclerotic renal artery stenosis
A Eirin, XY Zhu, JD Krier, H Tang, KL Jordan… - Stem …, 2012 - academic.oup.com
Reno‐protective strategies are needed to improve renal outcomes in patients with
atherosclerotic renal artery stenosis (ARAS). Adipose tissue‐derived mesenchymal stem …
atherosclerotic renal artery stenosis (ARAS). Adipose tissue‐derived mesenchymal stem …
Klotho as a potential biomarker and therapy for acute kidney injury
MC Hu, OW Moe - Nature reviews nephrology, 2012 - nature.com
Klotho is a single-pass transmembrane protein that is highly expressed in the kidney and is
known to act as a coreceptor for fibroblast growth factor 23. The extracellular domain can be …
known to act as a coreceptor for fibroblast growth factor 23. The extracellular domain can be …
Reversal of renal dysfunction by targeted administration of VEGF into the stenotic kidney: a novel potential therapeutic approach
AR Chade, S Kelsen - American Journal of Physiology …, 2012 - journals.physiology.org
Renal microvascular (MV) damage and loss contribute to the progression of renal injury in
renovascular disease (RVD). Whether a targeted intervention in renal microcirculation could …
renovascular disease (RVD). Whether a targeted intervention in renal microcirculation could …
Humanin prevents intra-renal microvascular remodeling and inflammation in hypercholesterolemic ApoE deficient mice
AIMS: Humanin (HN) is an endogenous mitochondrial-derived cytoprotective peptide that
has shown protective effects against atherosclerosis and is expressed in human vessels …
has shown protective effects against atherosclerosis and is expressed in human vessels …
Changes in glomerular filtration rate after renal revascularization correlate with microvascular hemodynamics and inflammation in Swine renal artery stenosis
Background—The selection of patients with renal artery stenosis (RAS) likely to improve
glomerular filtration rate (GFR) after percutaneous transluminal renal angioplasty is difficult …
glomerular filtration rate (GFR) after percutaneous transluminal renal angioplasty is difficult …
Statin inhibits hypoxia-induced endothelin-1 via accelerated degradation of HIF-1α in vascular smooth muscle cells
T Hisada, M Ayaori, N Ohrui, H Nakashima… - Cardiovascular …, 2012 - academic.oup.com
Abstract Aims Endothelin-1 (ET-1) contributes to the pathogenesis of cardiovascular
diseases with multiple properties such as vasoconstriction. Human ET-1 gene expression is …
diseases with multiple properties such as vasoconstriction. Human ET-1 gene expression is …
Therapeutic effects of a combinatorial treatment of simvastatin and bone marrow stromal cells on experimental embolic stroke
G Pirzad Jahromi, S Seidi, SS Sadr… - Basic & clinical …, 2012 - Wiley Online Library
In this study, we investigated the therapeutic effects of simvastatin administered in
combination with bone marrow stromal cells (BMSC s) following experimentally induced …
combination with bone marrow stromal cells (BMSC s) following experimentally induced …
Combination treatment of stroke with sub-therapeutic doses of Simvastatin and human umbilical cord blood cells enhances vascular remodeling and improves …
X Cui, M Chopp, A Zacharek, J Dai, C Zhang, T Yan… - Neuroscience, 2012 - Elsevier
Human umbilical cord blood cells (HUCBCs) have been employed as a restorative treatment
for experimental stroke. In this study, we investigated whether transplantation of sub …
for experimental stroke. In this study, we investigated whether transplantation of sub …