Pharmacological actions of statins: a critical appraisal in the management of cancer

P Gazzerro, MC Proto, G Gangemi, AM Malfitano… - Pharmacological …, 2012 - ASPET
Statins, among the most commonly prescribed drugs worldwide, are cholesterol-lowering
agents used to manage and prevent cardiovascular and coronary heart diseases. Recently …

Secreted klotho and chronic kidney disease

MC Hu, M Kuro-o, OW Moe - Endocrine FGFs and Klothos, 2012 - Springer
Soluble Klotho (sKl) in the circulation can be generated directly by alterative splicing of the
Klotho transcript or the extracellular domain of membrane Klotho can be released from …

Adipose tissue‐derived mesenchymal stem cells improve revascularization outcomes to restore renal function in swine atherosclerotic renal artery stenosis

A Eirin, XY Zhu, JD Krier, H Tang, KL Jordan… - Stem …, 2012 - academic.oup.com
Reno‐protective strategies are needed to improve renal outcomes in patients with
atherosclerotic renal artery stenosis (ARAS). Adipose tissue‐derived mesenchymal stem …

Klotho as a potential biomarker and therapy for acute kidney injury

MC Hu, OW Moe - Nature reviews nephrology, 2012 - nature.com
Klotho is a single-pass transmembrane protein that is highly expressed in the kidney and is
known to act as a coreceptor for fibroblast growth factor 23. The extracellular domain can be …

Reversal of renal dysfunction by targeted administration of VEGF into the stenotic kidney: a novel potential therapeutic approach

AR Chade, S Kelsen - American Journal of Physiology …, 2012 - journals.physiology.org
Renal microvascular (MV) damage and loss contribute to the progression of renal injury in
renovascular disease (RVD). Whether a targeted intervention in renal microcirculation could …

Humanin prevents intra-renal microvascular remodeling and inflammation in hypercholesterolemic ApoE deficient mice

X Zhang, VH Urbieta-Caceres, A Eirin, CC Bell… - Life sciences, 2012 - Elsevier
AIMS: Humanin (HN) is an endogenous mitochondrial-derived cytoprotective peptide that
has shown protective effects against atherosclerosis and is expressed in human vessels …

Changes in glomerular filtration rate after renal revascularization correlate with microvascular hemodynamics and inflammation in Swine renal artery stenosis

A Eirin, B Ebrahimi, X Zhang, XY Zhu… - Circulation …, 2012 - Am Heart Assoc
Background—The selection of patients with renal artery stenosis (RAS) likely to improve
glomerular filtration rate (GFR) after percutaneous transluminal renal angioplasty is difficult …

Statin inhibits hypoxia-induced endothelin-1 via accelerated degradation of HIF-1α in vascular smooth muscle cells

T Hisada, M Ayaori, N Ohrui, H Nakashima… - Cardiovascular …, 2012 - academic.oup.com
Abstract Aims Endothelin-1 (ET-1) contributes to the pathogenesis of cardiovascular
diseases with multiple properties such as vasoconstriction. Human ET-1 gene expression is …

Therapeutic effects of a combinatorial treatment of simvastatin and bone marrow stromal cells on experimental embolic stroke

G Pirzad Jahromi, S Seidi, SS Sadr… - Basic & clinical …, 2012 - Wiley Online Library
In this study, we investigated the therapeutic effects of simvastatin administered in
combination with bone marrow stromal cells (BMSC s) following experimentally induced …

Combination treatment of stroke with sub-therapeutic doses of Simvastatin and human umbilical cord blood cells enhances vascular remodeling and improves …

X Cui, M Chopp, A Zacharek, J Dai, C Zhang, T Yan… - Neuroscience, 2012 - Elsevier
Human umbilical cord blood cells (HUCBCs) have been employed as a restorative treatment
for experimental stroke. In this study, we investigated whether transplantation of sub …