Cytokine-induced killer (CIK) cells as feasible and effective adoptive immunotherapy for the treatment of solid tumors
G Mesiano, M Todorovic, L Gammaitoni… - Expert opinion on …, 2012 - Taylor & Francis
Introduction: Cytokine-induced killer (CIK) cells are heterogeneous ex vivo-expanded T
lymphocytes with mixed T-NK phenotype and endowed with a wide MHC-unrestricted …
lymphocytes with mixed T-NK phenotype and endowed with a wide MHC-unrestricted …
Natural killer cell lines in tumor immunotherapy
M Cheng, J Zhang, W Jiang, Y Chen, Z Tian - Frontiers of medicine, 2012 - Springer
Natural killer (NK) cells are considered to be critical players in anticancer immunity.
However, cancers are able to develop mechanisms to escape NK cell attack or to induce …
However, cancers are able to develop mechanisms to escape NK cell attack or to induce …
The anti-tumour activity of allogeneic cytokine-induced killer cells in patients who relapse after allogeneic transplant for haematological malignancies
YC Linn, M Niam, S Chu, A Choong, HX Yong… - Bone marrow …, 2012 - nature.com
We performed a Phase I/II clinical trial to study the feasibility, toxicity and efficacy of
allogeneic cytokine-induced killer (CIK) cell expansion, and treatment for patients with …
allogeneic cytokine-induced killer (CIK) cell expansion, and treatment for patients with …
Anti‐CD3× anti‐GD2 bispecific antibody redirects T‐cell cytolytic activity to neuroblastoma targets
M Yankelevich, SV Kondadasula… - Pediatric blood & …, 2012 - Wiley Online Library
Background The ganglioside GD2 is an attractive target for immunotherapy of
neuroectodermal tumors. We tested a unique bispecific antibody anti‐CD3× anti‐GD2 …
neuroectodermal tumors. We tested a unique bispecific antibody anti‐CD3× anti‐GD2 …
Review of Chinese clinical trials on CIK cell treatment for malignancies
XD Li, B Xu, J Wu, M Ji, BH Xu, JT Jiang… - Clinical and Translational …, 2012 - Springer
China is the country where the most clinical trials on CIK cells have been performed. We
aimed to provide definite evidence for using CIK cell treatment and extrapolate a common …
aimed to provide definite evidence for using CIK cell treatment and extrapolate a common …
Improved activation toward primary colorectal cancer cells by antigen‐specific targeting autologous cytokine‐induced killer cells
C Schlimper, AA Hombach, H Abken… - Journal of …, 2012 - Wiley Online Library
Adoptive therapy of malignant diseases with cytokine‐induced killer (CIK) cells showed
promise in a number of trials; the activation of CIK cells from cancer patients towards their …
promise in a number of trials; the activation of CIK cells from cancer patients towards their …
[HTML][HTML] Targeting cytomegalovirus-infected cells using T cells armed with anti-CD3× anti-CMV bispecific antibody
Human cytomegalovirus (CMV) reactivation and infection can lead to poor outcomes after
allogeneic stem cell transplantation. We hypothesized that anti-CD3 activated T cells (ATCs) …
allogeneic stem cell transplantation. We hypothesized that anti-CD3 activated T cells (ATCs) …
CIK cells–current status, clinical perspectives and future prospects–the good news
KM Hui - Expert Opinion on Biological Therapy, 2012 - Taylor & Francis
There is an ongoing explosion of knowledge in pursuing the adoptive immunotherapy of
cancer to offer an alternative and/or supplementary approach for the treatment of human …
cancer to offer an alternative and/or supplementary approach for the treatment of human …
Role of NKG2D in cytokine-induced killer cells against multiple myeloma cells
X Lu, A Zhu, X Cai, Z Jia, W Han, L Ma… - Cancer biology & …, 2012 - Taylor & Francis
The cytokine-induced killer cells (CIK) have been reported to have potent cytotoxicity against
a variety of tumor cells including multiple myleoma (MM) cells. The mechanisms that CIK cell …
a variety of tumor cells including multiple myleoma (MM) cells. The mechanisms that CIK cell …