Physical inactivity is an important contributor to non-communicable diseases in countries of
high income, and increasingly so in those of low and middle income. Understanding why …

The worldwide rising prevalence of obesity and insulin resistance is associated with a
parallel increase in nonalcoholic fatty liver disease (NAFLD). NAFLD is characterized by …

Stress and glucocorticoid stress hormones inhibit neurogenesis, whereas antidepressants
increase neurogenesis and block stress-induced decrease in neurogenesis. Our previous …

Glucose homeostasis is closely regulated not only by insulin, but also by leptin. Both
hormones act centrally, regulating food intake and adiposity in humans. Leptin has several …

The prevalence of obesity has been rapidly increasing worldwide over the last several
decades and has become a major health problem in developed countries. The brain …

The fat‐derived hormone, leptin, is well known to regulate body weight. However, there is
now substantial evidence that leptin also plays a primary role in the regulation of glucose …

The blood-brain barrier (BBB) separates the central nervous system (CNS) from the
peripheral tissues. However, this does not prevent hormones from entering the brain, but …

The studies based on candidate genes and encoded proteins known to cause severe
obesity in rodents, have shown that these genes also contribute to human early-onset …

The identification of leptin as a mediator of body weight regulation provided much initial
excitement for the treatment of obesity. Unfortunately, leptin monotherapy is insufficient in …

ÖzetObezitenin prevalansı tüm dünyada olduğu gibi ülkemizde de artmaktadır. Obezite
modern yaşantının doğal bir sonucu olarak görünmekte ve kardiyovasküler hastalıklar …