[HTML][HTML] Genetics of human cardiovascular disease
S Kathiresan, D Srivastava - Cell, 2012 - cell.com
Cardiovascular disease encompasses a range of conditions extending from myocardial
infarction to congenital heart disease, most of which are heritable. Enormous effort has been …
infarction to congenital heart disease, most of which are heritable. Enormous effort has been …
Innate lymphoid cells: emerging insights in development, lineage relationships, and function
Innate lymphoid cells (ILCs) are immune cells that lack a specific antigen receptor yet can
produce an array of effector cytokines that in variety match that of T helper cell subsets. ILCs …
produce an array of effector cytokines that in variety match that of T helper cell subsets. ILCs …
IL-33–responsive lineage− CD25+ CD44hi lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs
KR Bartemes, K Iijima, T Kobayashi… - The Journal of …, 2012 - journals.aai.org
Innate immunity provides the first line of response to invading pathogens and a variety of
environmental insults. Recent studies identified novel subsets of innate lymphoid cells that …
environmental insults. Recent studies identified novel subsets of innate lymphoid cells that …
Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33
MAM Willart, K Deswarte, P Pouliot, H Braun… - Journal of Experimental …, 2012 - rupress.org
House dust mite (HDM) is one of the most common allergens worldwide. In this study, we
have addressed the involvement of IL-1 in the interaction between HDM and the innate …
have addressed the involvement of IL-1 in the interaction between HDM and the innate …
[HTML][HTML] Lung eQTLs to help reveal the molecular underpinnings of asthma
Genome-wide association studies (GWAS) have identified loci reproducibly associated with
pulmonary diseases; however, the molecular mechanism underlying these associations are …
pulmonary diseases; however, the molecular mechanism underlying these associations are …
Genome-wide association analysis identifies three new breast cancer susceptibility loci
Breast cancer is the most common cancer among women. To date, 22 common breast
cancer susceptibility loci have been identified accounting for∼ 8% of the heritability of the …
cancer susceptibility loci have been identified accounting for∼ 8% of the heritability of the …
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease
We performed a meta-analysis of 2 genome-wide association studies of coronary artery
disease comprising 1,515 cases and 5,019 controls followed by replication studies in 15,460 …
disease comprising 1,515 cases and 5,019 controls followed by replication studies in 15,460 …
Pediatric and adult eosinophilic esophagitis: similarities and differences
A Straumann, SS Aceves, C Blanchard, MH Collins… - Allergy, 2012 - Wiley Online Library
Early in the 1990s, several case series described adults suffering from dysphagia and
children with refractory reflux symptoms, both accompanied by an eosinophil‐predominant …
children with refractory reflux symptoms, both accompanied by an eosinophil‐predominant …
Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity
BACKGROUND: Asthma has been considered an immunologic disease mediated by TH2
cells and adaptive immunity. However, clinical and experimental observations suggest that …
cells and adaptive immunity. However, clinical and experimental observations suggest that …
Genome-wide association study to identify genetic determinants of severe asthma
Background The genetic basis for developing asthma has been extensively studied.
However, association studies to date have mostly focused on mild to moderate disease and …
However, association studies to date have mostly focused on mild to moderate disease and …