Cardiovascular disease is the leading cause of death in the US and worldwide. Failure to
properly repair or regenerate damaged cardiac tissues after myocardial infarction is a major …

The zebrafish is a widely used model animal to study the regeneration of organs, such as
the fin and heart. Their average lifetime is about 3 years, and recent studies have shown that …

Ubiquitin-like, containing PHD and RING finger domains 1 (uhrf1) is regulated at the
transcriptional level during the cell cycle and in developing zebrafish embryos. We identify …

Different from tetrapods, teleost vertebral centra form without prior establishment of a
cartilaginous scaffold, in two steps: First, mineralization of the notochord sheath establishes …

Ribosome biogenesis in the nucleolus requires numerous nucleolar proteins and small non-
coding RNAs. Among them is ribosome biogenesis factor Bms1, which is highly conserved …

Augmenter of Liver Regeneration (ALR) is a sulfhydryl oxidase carrying out fundamental
functions facilitating protein disulfide bond formation. In mammals, it also functions as a …

In certain vertebrates such as the zebrafish, most tissues and organs including the heart and
central nervous system possess the remarkable ability to regenerate following severe injury …

Sorting nexin (SNX) family proteins are best characterized for their abilities to regulate
protein trafficking during processes such as endocytosis of membrane receptors, endosomal …

During newt lens regeneration a unique transdifferentiation event occurs. In this process,
dorsal iris pigmented epithelial cells transdifferentiate into lens cells. This system should …

Cirrhosis remains one of the central challenges in clinical hepatology. It is the common final
outcome of a variety of diseases, including chronic alcohol intake, steatohepatitis, viral …