Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

The discovery that kisspeptin was critical for normal fertility in humans ushered in a new
chapter in our understanding of the control of GnRH secretion. In this paper, we will review …

Kisspeptins (Kp), products of the Kiss1 gene that act via Gpr54 to potently stimulate GnRH
secretion, operate as mediators of other regulatory signals of the gonadotropic axis. Mouse …

Objective The incidence of idiopathic precocious puberty (IPP) might have an increasing
trend. But the causes and risk factors of IPP are unknown. The objective of our study is to …

OBJECTIVE: To investigate the presence of variants in the TAC3 and TACR3 genes, which
encode NKB and its receptor (NK3R), respectively, in a large cohort of patients with …

The major determinants of the variability in pubertal maturation are reported to be genetic
and inherited. Nonetheless, nutritional status contributes significantly to this variability …

The kisspeptin system plays an essential role in reproductive function in vertebrates,
particularly in the onset of puberty. We investigated the kisspeptin system in two Perciform …

KiSS1 and its cognate G-protein-coupled receptor, GPR54, have diverse functions. While
KiSS1 and GPR54 have been intensively studied in physiology, their role in cancer is still …

Kisspeptins, the peptide products of the KiSS-1 gene, bind to the G protein coupled receptor
54 (GPR54). Since 2003, research has revealed the important role of kisspeptins in initiating …

Aim: To investigate LIN28B gene variants in children with idiopathic central precocious
puberty (CPP). Patients and Methods: We studied 178 Brazilian children with CPP (171 girls …