The introduction of corticosteroids more than 50 years ago dramatically improved the
prognosis of children with nephrotic syndrome. Corticosteroids remain the standard initial …

Ca2+-mediated remodeling of the actin cytoskeleton is a dynamic process that regulates cell
motility through the modulation of rho guanosine triphosphatase (GTPase) signaling. Kidney …

Rho family GTPases are molecular switches best known for their pivotal role in dynamic
regulation of the actin cytoskeleton. The prototypic members of this family are Cdc42, Rac1 …

Observations of hereditary glomerular disease support the contention that podocyte
intercellular junction proteins are essential for junction formation and maintenance. Genetic …

Nephrotic syndrome is a disorder of the glomerular filtration barrier, and central to the
filtration mechanism of the glomerular filtration barrier is the podocyte. We are starting to …

Focal segmental glomerulosclerosis (FSGS) is the most common primary glomerular
disorder causing end-stage renal disease. Since the first description of this …

In an attempt to understand the basis of glomerular disease, significant progress has been
made in understanding the mechanisms that determine podocyte development and the …

The podocyte is a key cell in the selective filtering action of the glomerular capillary wall.
Podocyte injury is of pathogenetic and prognostic significance in human glomerular disease; …

During the past 2 decades, progress has been made in understanding the biology and
mechanisms of podocyte injury and the relationship of these processes to …

Proteinuria is often accompanied by a pathological change in the glomerulus that is refereed
as effacement of the podocyte foot processes. The highly dynamic podocyte foot processes …