Assessing cell and organ senescence biomarkers
BB de Jesus, MA Blasco - Circulation research, 2012 - Am Heart Assoc
A major goal in cancer and aging research is to discriminate the biochemical modifications
that happen locally that could account for the healthiness or malignancy of tissues …
that happen locally that could account for the healthiness or malignancy of tissues …
Acute promyelocytic leukemia, arsenic, and PML bodies
H de Thé, M Le Bras… - Journal of Cell Biology, 2012 - rupress.org
Acute promyelocytic leukemia (APL) is driven by a chromosomal translocation whose
product, the PML/retinoic acid (RA) receptor α (RARA) fusion protein, affects both nuclear …
product, the PML/retinoic acid (RA) receptor α (RARA) fusion protein, affects both nuclear …
Curing APL through PML/RARA degradation by As2O3
V Lallemand-Breitenbach, J Zhu, Z Chen - Trends in molecular medicine, 2012 - cell.com
Acute promyelocytic leukemia (APL) is a hematological malignancy driven by the
PML/RARA oncogene. The prognosis for patients with APL was revolutionized by two …
PML/RARA oncogene. The prognosis for patients with APL was revolutionized by two …
E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis
K Wolyniec, J Shortt, E de Stanchina… - Blood, The Journal …, 2012 - ashpublications.org
Neoplastic transformation requires the elimination of key tumor suppressors, which may
result from E3 ligase-mediated proteasomal degradation. We previously demonstrated a key …
result from E3 ligase-mediated proteasomal degradation. We previously demonstrated a key …
Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence
N Martin, M Benhamed, K Nacerddine… - The EMBO …, 2012 - embopress.org
Cellular senescence acts as a potent barrier for tumour initiation and progression. Previous
studies showed that the PML tumour suppressor promotes senescence, although the …
studies showed that the PML tumour suppressor promotes senescence, although the …
Role of the promyelocytic leukaemia protein in cell death regulation
P Salomoni, M Dvorkina, D Michod - Cell death & disease, 2012 - nature.com
The promyelocytic leukaemia gene PML was originally identified at the t (15; 17)
translocation of acute promyelocytic leukaemia, which generates the oncogene PML-retinoic …
translocation of acute promyelocytic leukaemia, which generates the oncogene PML-retinoic …
Mutation associations in RA-defiant APL
SJ Chen - Blood, The Journal of the American Society of …, 2012 - ashpublications.org
Intrinsic or acquired resistance to anticancer drugs can arise from a variety of factors
including the development of mutations in drug targets and additional genetic abnormalities …
including the development of mutations in drug targets and additional genetic abnormalities …
A new feature of CK2 function: it's role in granulocytic differentiation induced by retinoic acid
L Quotti Tubi - 2012 - research.unipd.it
ABSTRACT The Ser/Thr kinase CK2 promotes cell survival and proliferation 1; it also
modulates a number of molecules involved in cell development 2, 3, 4, 5, 6. In this study, we …
modulates a number of molecules involved in cell development 2, 3, 4, 5, 6. In this study, we …
Characterising the role of trim16 in differentiation, proliferation and tumour development in neuroblastoma
JL Bell - 2012 - unsworks.unsw.edu.au
dc. description. abstract Neuroblastoma is the most common solid tumour in childhood and
represents a significant 15% of all cancer deaths in children. Retinoids are used in the …
represents a significant 15% of all cancer deaths in children. Retinoids are used in the …