The role of endocannabinoids as inhibitory retrograde transmitters is now widely known and
intensively studied. However, endocannabinoids also influence neuronal activity by exerting …

The diacylglycerol lipases (DAGLs) hydrolyse diacylglycerol to generate 2-
arachidonoylglycerol (2-AG), the most abundant ligand for the CB1 and CB2 cannabinoid …

This review focuses on the endocannabinoid system as a crucial player during critical
periods of brain development, and how its disturbance either by early life stressful events or …

During brain development, neurogenesis is precisely regulated by the concerted action of
intrinsic factors and extracellular signalling systems that provide the necessary niche …

Endogenous cannabinoids (endocannabinoids, eCBs) are ubiquitous regulators of synaptic
transmission in the brain, mediating numerous forms of short‐and long‐term plasticity, and …

The importance of adult neurogenesis has only recently been accepted, resulting in a
completely new field of investigation within stem cell biology. The regulation and functional …

Alterations in emotion regulation processes may form the basis of psychopathologies. The
endocannabinoid (eCB) system, composed of endogenous ligands, the enzymatic …

The field of cannabinoid (CB) drug research is experiencing a challenge as the CB1
antagonist Rimonabant, launched in 2006 as an anorectic/anti-obesity drug, was withdrawn …

Alcohol (ethanol) is a teratogen that adversely affects nervous system development in a
wide range of animal species. In humans numerous congenital abnormalities arise as a …

Background The endocannabinoid 2-arachidonoyl glycerol (2-AG) acts as a retrograde
messenger and modulates synaptic signaling eg in the hippocampus. 2-AG also exerts …