[HTML][HTML] Gap junctional channels are parts of multiprotein complexes

JC Hervé, M Derangeon, D Sarrouilhe… - … et Biophysica Acta (BBA …, 2012 - Elsevier
Gap junctional channels are a class of membrane channels composed of transmembrane
channel-forming integral membrane proteins termed connexins, innexins or pannexins that …

Sepsis: going to the heart of the matter

MRN Celes, CM Prado, MA Rossi - Pathobiology, 2012 - karger.com
Although myocardial depression is the predominant cause of death in severe sepsis/septic
shock, it remains disputed whether the functional changes are a consequence of structural …

Cx43 Associates with Nav1.5 in the Cardiomyocyte Perinexus

JM Rhett, EL Ongstad, J Jourdan… - The Journal of membrane …, 2012 - Springer
Gap junctions (GJs) are aggregates of channels that provide for direct cytoplasmic
connection between cells. Importantly, this connection is thought responsible for cell-to-cell …

[HTML][HTML] Functional redundancy and compensation among members of gap junction protein families?

P Bedner, C Steinhäuser, M Theis - Biochimica et Biophysica Acta (BBA) …, 2012 - Elsevier
Gap junctions are intercellular conduits for small molecules made up by protein subunits
called connexins. A large number of connexin genes were found in mouse and man, and …

Gating of connexin 43 gap junctions by a cytoplasmic loop calmodulin binding domain

Q Xu, RF Kopp, Y Chen, JJ Yang… - … of Physiology-Cell …, 2012 - journals.physiology.org
Calmodulin (CaM) binding sites were recently identified on the cytoplasmic loop (CL) of at
least three α-subfamily connexins (Cx43, Cx44, Cx50), while Cx40 does not have this …

The role of connexins in prostate cancer promotion and progression

J Czyż, K Szpak, Z Madeja - Nature Reviews Urology, 2012 - nature.com
Prostate cancer is a prevalent disease that is characterized by a presumably long latency
period and a moderate propensity to metastasize. Although a range of mechanisms have …

High glucose-induced hypertrophy of mesangial cells is reversed by connexin43 overexpression via PTEN/Akt/mTOR signaling

L Liu, X Hu, GY Cai, Y Lv, L Zhuo, JJ Gao… - Nephrology Dialysis …, 2012 - academic.oup.com
Background. Hypertrophy of glomerular mesangial cells (GMC) is one of the earliest
pathological abnormalities in diabetic nephropathy, which correlates with eventual …

The effector and scaffolding proteins AF6 and MUPP1 interact with connexin36 and localize at gap junctions that form electrical synapses in rodent brain

X Li, BD Lynn, JI Nagy - European Journal of Neuroscience, 2012 - Wiley Online Library
Electrical synapses formed by neuronal gap junctions composed of connexin36 (Cx36)
occur in most major structures in the mammalian central nervous system. These synapses …

The connexin mimetic peptide Gap27 increases human dermal fibroblast migration in hyperglycemic and hyperinsulinemic conditions in vitro

CS Wright, S Pollok, DJ Flint… - Journal of cellular …, 2012 - Wiley Online Library
Significant increases in skin wound healing rates occur by reducing connexin‐mediated
communication (CMC). Gap27, a connexin (Cx) mimetic peptide targeted to the second …

Enhanced chondrogenic differentiation potential of human gingival fibroblasts by spheroid formation on chitosan membranes

S Hsu, GS Huang, SYF Lin, F Feng, TT Ho… - … Engineering Part A, 2012 - liebertpub.com
Human gingival fibroblasts (HGF) were recently found to be a source of mesenchymal stem
cells. Their behavior on a biomaterial has not been reported so far. The effect of culturing …