Doxil®, the first FDA-approved nano-drug (1995), is based on three unrelated principles:(i)
prolonged drug circulation time and avoidance of the RES due to the use of PEGylated nano …

Many tumor cells become resistant to commonly used cytotoxic drugs due to the
overexpression of ATP-binding cassette (ABC) transporters, namely P-glycoprotein (P-gp) …

Children with Down syndrome (DS) often present with hematopoietic abnormalities, and are
at increased risk of developing leukemia. Specifically, 3–10% of newborns with DS are …

For decades, the hallmark of medical treatment for cancer has been intravenous cytotoxic
chemotherapy, where these drugs target rapidly dividing cells, including cancer cells and …

The transcription factor nuclear factor-κB (NF-κB) is a main regulator of the expression of
several genes involved in the activation of inflammation, cell proliferation, cell immunity and …

Targeted cancer therapies use drugs that specially reach at the affected site block the
growth and spread of cancer. They interfere with specific molecules involved in …

Crystal structures of polymorphs α and β of imatinib mesylate were obtained. Thermal
behavior and grinding effects were studied by X-ray powder diffraction and differential …

The incidence of thyroid cancer continues to increase and this neoplasia remains the most
common endocrine malignancy. No effective systemic treatment currently exists for iodine …

Purpose Systemically administered fludarabine phosphate (F-araAMP) slows growth of
human tumor xenografts that express Escherichia coli purine nucleoside phosphorylase …

Abstract Treatment of cancer involves a multidisciplinary approach consisting of surgery,
chemotherapy, molecular targeted therapy and radiation therapy. These therapies work on …