HECT and RING finger families of E3 ubiquitin ligases at a glance
MB Metzger, VA Hristova… - Journal of cell …, 2012 - journals.biologists.com
This article is part of a Minifocus on Ubiquitin. For further reading, please see related
articles: ʻUbiquitin and SUMO in DNA repair at a glanceʼ by Helle D. Ulrich (J. Cell Sci …
articles: ʻUbiquitin and SUMO in DNA repair at a glanceʼ by Helle D. Ulrich (J. Cell Sci …
Protein quality control in the ER: balancing the ubiquitin checkbook
JHL Claessen, L Kundrat, HL Ploegh - Trends in cell biology, 2012 - cell.com
Protein maturation in the endoplasmic reticulum (ER) is subject to stringent quality control.
Terminally misfolded polypeptides are usually ejected into the cytoplasm and targeted for …
Terminally misfolded polypeptides are usually ejected into the cytoplasm and targeted for …
Critical Role of Types 2 and 3 Deiodinases in the Negative Regulation of Gene Expression by T3 in the Mouse Cerebral Cortex
A Hernandez, B Morte, MM Belinchón… - …, 2012 - academic.oup.com
Thyroid hormones regulate brain development and function through the control of gene
expression, mediated by binding of T3 to nuclear receptors. Brain T3 concentration is tightly …
expression, mediated by binding of T3 to nuclear receptors. Brain T3 concentration is tightly …
Identification of iopanoic acid as substrate of type 1 deiodinase by a novel nonradioactive iodide-release assay
K Renko, CS Hoefig, F Hiller, L Schomburg… - …, 2012 - academic.oup.com
Enzymatic 5'-and 5-deiodination are key reactions for local and systemic activation and
inactivation of iodothyronines and thyronamines. Expression of the three deiodinase (DIO) …
inactivation of iodothyronines and thyronamines. Expression of the three deiodinase (DIO) …
Selective destruction of abnormal proteins by ubiquitin-mediated protein quality control degradation
EK Fredrickson, RG Gardner - Seminars in cell & developmental biology, 2012 - Elsevier
Misfolded proteins are continuously produced in the cell and present an escalating
detriment to cellular physiology if not managed effectively. As such, all organisms have …
detriment to cellular physiology if not managed effectively. As such, all organisms have …
E3 ubiquitin ligases in protein quality control mechanism
D Chhangani, AP Joshi, A Mishra - Molecular neurobiology, 2012 - Springer
In living cells, polypeptide chains emerging from ribosomes and preexisting polypeptide
chains face constant threat of misfolding and aggregation. To prevent protein aggregation …
chains face constant threat of misfolding and aggregation. To prevent protein aggregation …
A novel locus for body mass index on 5p15. 2: a meta-analysis of two genome-wide association studies
KS Wang, X Liu, S Zheng, M Zeng, Y Pan, K Callahan - Gene, 2012 - Elsevier
OBJECTIVE: Genetic factors play an important role in modulating the vulnerability to body
mass index (BMI). The purpose of this study is to identify novel genetic variants for BMI using …
mass index (BMI). The purpose of this study is to identify novel genetic variants for BMI using …
Statins and downstream inhibitors of the isoprenylation pathway increase type 2 iodothyronine deiodinase activity
BT Miller, CB Ueta, V Lau, KG Jacomino… - …, 2012 - academic.oup.com
The type 2 iodothyronine selenodeiodinase (D2) is a critical determinant of local thyroid
signaling, converting T4 to the active form T3 at the cytoplasmic face of the endoplasmic …
signaling, converting T4 to the active form T3 at the cytoplasmic face of the endoplasmic …