Chronic kidney disease (CKD) is a public health epidemic that affects millions of people
worldwide. Presence of CKD predisposes individuals to high risks of end-stage renal …

Osteoporosis is an important age-related bone disease characterized by increased bone
turnover with insufficient bone formation relative to bone resorption. According to the current …

Background Disorders of mineral metabolism, including secondary hyperparathyroidism, are
thought to contribute to extraskeletal (including vascular) calcification among patients with …

Tight regulation of calcium levels is required for many critical biological functions. The Ca2+-
sensing receptor (CaSR) expressed by parathyroid cells controls blood calcium …

Background The aim of the present study was to evaluate the outcome of different surgical
procedures for patients on permanent dialysis who underwent initial parathyroidectomy for …

All currently efficacious antipsychotic drugs have as part of their mechanism the ability to
attenuate some or all of the signaling through the dopamine D 2 receptor. More recently, the …

Background. Elevated fibroblast growth factor 23 (FGF23) is associated with adverse clinical
outcomes and development of secondary hyperparathyroidism (SHPT) refractory to active …

Calciphylaxis, also known as calcific uremic arteriolopathy, is a cutaneous ischemic small
vessel vasculopathy seen in 1 to 4% of patients with chronic kidney disease on …

For kidney transplant recipients, immunosuppression commonly consists of combination
treatment with a calcineurin inhibitor, an antiproliferative agent and a corticosteroid. Many …

Background Optimal treatment for secondary hyperparathyroidism (SHPT) has not been
defined. The IMPACT SHPT (ClinicalTrials. gov identifier: NCT00977080) study assessed …